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Molecules 2019, 24(4), 656; https://doi.org/10.3390/molecules24040656

High Sensitive Immunoelectrochemical Measurement of Lung Cancer Tumor Marker ProGRP Based on TiO2-Au Nanocomposite

1
Department of Oncology, Henan Academy Institute of Traditional Chinese Medicine, Zhengzhou 450000, Henan, China
2
School of Basic Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou 450002, Henan, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Yulia H. Budnikova
Received: 19 December 2018 / Revised: 31 January 2019 / Accepted: 6 February 2019 / Published: 13 February 2019
(This article belongs to the Special Issue Organic Electrochemistry 2019)
Full-Text   |   PDF [2363 KB, uploaded 13 February 2019]   |  
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Abstract

Progastrin-releasing peptide (ProGRP), which is known to be highly specific and sensitive to small cell lung cancer (SCLC), has been proven to be a valuable substitute for neuron-specific enolase in SCLC diagnostics and monitoring, especially in its early stages. The detection of ProGRP levels also facilitates a selection of therapeutic treatments. For the fabrication of our proposed biosensor, titanium (IV) oxide microparticles were first used, followed by dispersing gold nanoparticles into chitosan and immobilizing them onto a carbon paste electrode (CPE) surface. The developed immunosensor exhibits a much higher biosensing performance in comparison with current methods, when it comes to the detection of ProGRP. Therefore, the proposed CPE/TiO2/(CS+AuNPs)/anti-ProGRP/BSA/ProGRP is excellent for the development of a compact diagnostics apparatus. View Full-Text
Keywords: progastrin-releasing peptide; immunosensor; small cell lung cancer; clinic diagnosis; titanium (IV) oxide microparticles progastrin-releasing peptide; immunosensor; small cell lung cancer; clinic diagnosis; titanium (IV) oxide microparticles
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Wei, Z.; Cai, X.; Zhang, J.; Fan, J.; Xu, J.; Xu, L. High Sensitive Immunoelectrochemical Measurement of Lung Cancer Tumor Marker ProGRP Based on TiO2-Au Nanocomposite. Molecules 2019, 24, 656.

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