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Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems

Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, China
College of Food Science and technology, Nanjing Agricultural University, Nanjing 210095, China
Authors to whom correspondence should be addressed.
These people were contributed equally.
Molecules 2019, 24(19), 3628;
Received: 11 September 2019 / Revised: 29 September 2019 / Accepted: 7 October 2019 / Published: 8 October 2019
(This article belongs to the Section Natural Products Chemistry)
Two new triterpenoids, named kadsuricoccins A and B, together with three known ones, were isolated from the Li folk herb Heilaohu, the stems of Kadsura coccinea (Lem.) A. C. Smith, which was used for food and as a healthy supplement. Their structures were elucidated by comprehensive analyses of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data. To search healthy components, an acetylcholinesterase (AChE) inhibitory activity test by Ellman’s Method was conducted, kadsuricoccins A and B showed activity with the AChE inhibit index (AII) up to 68.96% ± 0.19% and 57.8% ± 0.11% at 94 nM (compared with positive control tacrine AII 79.80% ± 0.20%, 9.4 nM), respectively. View Full-Text
Keywords: Kadsura coccinea; Schisandraceae; AChE inhibitor; triterpenoid Kadsura coccinea; Schisandraceae; AChE inhibitor; triterpenoid
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MDPI and ACS Style

Huang, S.Z.; Duan, L.P.; Wang, H.; Mei, W.L.; Dai, H.F. Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems. Molecules 2019, 24, 3628.

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