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Open AccessFeature PaperReview

Red Wine Consumption and Cardiovascular Health

1
Department of Pharmacy, Faculty of Pharmacy, University of Naples “Federico II”, Via Domenico Montesano 49, 80131 Naples, Italy
2
Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Via S. Pansini 5, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Susana M. Cardoso and Alessia Fazio
Molecules 2019, 24(19), 3626; https://doi.org/10.3390/molecules24193626
Received: 16 September 2019 / Revised: 1 October 2019 / Accepted: 7 October 2019 / Published: 8 October 2019
(This article belongs to the Special Issue The Antioxidant Capacities of Natural Products 2019)
Wine is a popular alcoholic beverage that has been consumed for hundreds of years. Benefits from moderate alcohol consumption have been widely supported by the scientific literature and, in this line, red wine intake has been related to a lesser risk for coronary heart disease (CHD). Experimental studies and meta-analyses have mainly attributed this outcome to the presence in red wine of a great variety of polyphenolic compounds such as resveratrol, catechin, epicatechin, quercetin, and anthocyanin. Resveratrol is considered the most effective wine compound with respect to the prevention of CHD because of its antioxidant properties. The mechanisms responsible for its putative cardioprotective effects would include changes in lipid profiles, reduction of insulin resistance, and decrease in oxidative stress of low-density lipoprotein cholesterol (LDL-C). The aim of this review is to summarize the accumulated evidence correlating moderate red wine consumption with prevention of CHD by focusing on the different mechanisms underlying this relationship. Furthermore, the chemistry of wine as well as chemical factors that influence the composition of the bioactive components of red wine are also discussed. View Full-Text
Keywords: red wine; resveratrol; polyphenols; alcohol; cardioprotective; antioxidants red wine; resveratrol; polyphenols; alcohol; cardioprotective; antioxidants
MDPI and ACS Style

Castaldo, L.; Narváez, A.; Izzo, L.; Graziani, G.; Gaspari, A.; Di Minno, G.; Ritieni, A. Red Wine Consumption and Cardiovascular Health. Molecules 2019, 24, 3626.

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