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Open AccessFeature PaperArticle

Effects of the Ethanol Extract of Dipterocarpus alatus Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action

1
Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
2
Department of Horticulture, Faculty of Agriculture, Killis 7 Aralik University, Killis 79000, Turkey
3
ICBAS-Instituto de Ciências Biomédicas Abel Salazar and CIIMAR, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2019, 24(18), 3396; https://doi.org/10.3390/molecules24183396
Received: 30 August 2019 / Revised: 11 September 2019 / Accepted: 17 September 2019 / Published: 18 September 2019
(This article belongs to the Special Issue Selected Papers from the Joint Symposia of MESMAP-5 & ISPBS-5)
Treatment of the unpredictable chronic mild stress (UCMS) mice with the ethanol extract of Dipterocarpus alatus leaf attenuated anhedonia (increased sucrose preference) and behavioral despair (decreased immobility time in tail suspension test (TST) and forced swimming test (FST)). The extract not only decreased the elevation of serum corticosterone level and the index of over-activation of the hypothalamic-pituitary-adrenal (HPA) axis, caused by UCMS, but also ameliorated UCMS-induced up-regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) mRNA expression and down-regulation of cyclic AMP-responsive element binding (CREB) and brain-derived neurotrophic factor (BDNF) mRNAs in frontal cortex and hippocampus. In vitro monoamine oxidase (MAO) inhibition assays showed that the extract exhibited the partial selective inhibition on MAO-A. HPLC analysis of the extract showed the presence of flavonoids (luteolin-7-O-glucoside, kaempferol-3-glucoside, rutin) and phenolic acids (gallic acid, ferulic acid, and caffeic acid) as major constituents. View Full-Text
Keywords: Dipterocarpus alatus; flavonoids; depression; UCMS; HPA axis; neurogenesis; MAO-A inhibition Dipterocarpus alatus; flavonoids; depression; UCMS; HPA axis; neurogenesis; MAO-A inhibition
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MDPI and ACS Style

Daodee, S.; Monthakantirat, O.; Ruengwinitwong, K.; Gatenakorn, K.; Maneenet, J.; Khamphukdee, C.; Sekeroglu, N.; Chulikhit, Y.; Kijjoa, A. Effects of the Ethanol Extract of Dipterocarpus alatus Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action. Molecules 2019, 24, 3396. https://doi.org/10.3390/molecules24183396

AMA Style

Daodee S, Monthakantirat O, Ruengwinitwong K, Gatenakorn K, Maneenet J, Khamphukdee C, Sekeroglu N, Chulikhit Y, Kijjoa A. Effects of the Ethanol Extract of Dipterocarpus alatus Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action. Molecules. 2019; 24(18):3396. https://doi.org/10.3390/molecules24183396

Chicago/Turabian Style

Daodee, Supawadee; Monthakantirat, Orawan; Ruengwinitwong, Kanlaya; Gatenakorn, Kankrittanon; Maneenet, Juthamart; Khamphukdee, Charinya; Sekeroglu, Nazim; Chulikhit, Yaowared; Kijjoa, Anake. 2019. "Effects of the Ethanol Extract of Dipterocarpus alatus Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action" Molecules 24, no. 18: 3396. https://doi.org/10.3390/molecules24183396

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