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Open AccessArticle

Inhibitory Effects of Scutellaria baicalensis Root Extract on Linoleic Acid Hydroperoxide-induced Lung Mitochondrial Lipid Peroxidation and Antioxidant Activities

by Pei Ru Liau 1, Ming Shun Wu 2,3,* and Ching Kuo Lee 1,*
1
School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan
2
Division of Gastroenterology, Department of Internal Medicine, Wan Fang Hospital, Taipei 11661, Taiwan
3
School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: María Pilar Almajano
Molecules 2019, 24(11), 2143; https://doi.org/10.3390/molecules24112143
Received: 12 May 2019 / Revised: 3 June 2019 / Accepted: 5 June 2019 / Published: 6 June 2019
(This article belongs to the Special Issue Antioxidants Chemistry and Applications)
In this study, we evaluated the ability of Scutellaria baicalensis Georgi to protect lipid-peroxidation (LPO) in lung tissue after free radical-induced injury. We prepared S. baicalensis root (SBR) extracts using different solvents. The total flavonoid and total phenol contents of each extract were measured, and the ROS damage protection was evaluated by analyzing linoleic acid hydroperoxide (LHP)-induced LPO in rat lung mitochondria. Moreover, evaluating diphenylpicrylhydrazyl (DPPH), hydrogen peroxide, superoxide anion radical, and hydroxyl radical scavenging abilities and using metal chelating assays were used to determine in vitro antioxidant activity. The ethyl acetate (EtOAc) extract showed high ROS scavenging ability, and four compounds were subsequently isolated and purified from this extract: baicalin, baicalein, wogonin, and oroxylin A. Baicalein in rat lung mitochondria the most significant LHP-induced LPO inhibition was shown and extracted with EtOAc that contained the highest amount of baicalein. Thus, baicalein and the EtOAc extract of SBR may be efficient in conferring ROS damage protection and inhibiting LHP-induced LPO in rat lung mitochondria. Additional studies are warranted to investigate their use as antioxidant therapy for respiration infections, nutrition supplements, and lead compounds in pharmaceuticals. View Full-Text
Keywords: Scutellaria baicalensis; phytochemical; rat lung; lipid peroxidation; antioxidant Scutellaria baicalensis; phytochemical; rat lung; lipid peroxidation; antioxidant
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Liau, P.R.; Wu, M.S.; Lee, C.K. Inhibitory Effects of Scutellaria baicalensis Root Extract on Linoleic Acid Hydroperoxide-induced Lung Mitochondrial Lipid Peroxidation and Antioxidant Activities. Molecules 2019, 24, 2143.

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