Next Article in Journal
Validation of Internal Control Genes for Quantitative Real-Time PCR Gene Expression Analysis in Morchella
Previous Article in Journal
Identification of Bioactive Chemical Markers in Zhi zhu xiang Improving Anxiety in Rat by Fingerprint-Efficacy Study
Previous Article in Special Issue
Synthesis of Novel 1,4-Naphthoquinones Possessing Indole Scaffolds Using In(OTf)3 in Solvent-Free Conditions
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Molecules 2018, 23(9), 2330; https://doi.org/10.3390/molecules23092330

Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents

1
School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China
2
SanQuan Medical College, Xinxiang Medical University, Xinxiang 453003, China
*
Author to whom correspondence should be addressed.
Received: 28 July 2018 / Revised: 30 August 2018 / Accepted: 3 September 2018 / Published: 12 September 2018
(This article belongs to the Special Issue Multicomponent Reactions)
Full-Text   |   PDF [1179 KB, uploaded 12 September 2018]   |  

Abstract

A series of novel spirooxindole-O-naphthoquinone-tetrazolo[1,5-a]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents. These hybrids exhibited relatively high cytotoxic activity against cancer cell line HepG2 (IC50 = 2.86–36.34 μM), while normal cell line LO2 was less sensitive to these hybrids (IC50 = 36.37–248.39 μM). On the whole, among all the compounds tested, compound 4e, with a mean IC50 value of 2.86 μM, was the most active. The novel hybrids may find their pharmaceutical applications after further investigations. View Full-Text
Keywords: spirooxindole; O-naphthoquinone; hybrids; antitumor activity spirooxindole; O-naphthoquinone; hybrids; antitumor activity
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Wu, L.; Liu, Y.; Li, Y. Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents. Molecules 2018, 23, 2330.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top