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Molecules, Volume 23, Issue 7

July 2018 - 338 articles

Cover Story: DNA nanostructures can be simply programmed into a wide variety of shapes. One application of such approaches is in the display of nucleic acid aptamers to improve their efficacy in molecular recognition for diagnostics or bioelectronics. Here, we compare the characteristics of several DNA polyhedra in the display of an aptamer that binds to a protein biomarker for malaria diagnosis. The display of aptamers on DNA polyhedra provides a simple approach with which to improve aptamer efficacy in a wide variety of applications. View the paper here.
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Articles (338)

  • Feature Paper
  • Communication
  • Open Access
13 Citations
11,378 Views
14 Pages

Rolling circle amplification (RCA) is a robust way to generate DNA constructs, which are promising materials for biomedical applications including drug delivery because of their high biocompatibility. To be employed as a drug delivery platform, howev...

  • Review
  • Open Access
57 Citations
10,713 Views
18 Pages

Progress in Metabonomics of Type 2 Diabetes Mellitus

  • Quantao Ma,
  • Yaqi Li,
  • Min Wang,
  • Ziyan Tang,
  • Ting Wang,
  • Chenyue Liu,
  • Chunguo Wang and
  • Baosheng Zhao

With the improvement of living standards and a change in lifestyle, the incidence of type 2 diabetes mellitus (T2DM) is increasing. Its etiology is too complex to be completely understand yet. Metabonomics techniques are used to study the changes of...

  • Article
  • Open Access
9 Citations
5,144 Views
18 Pages

The role of ginseng berry extract (GBE) has been attributed to its anti-hyperglycemic effect in humans. However, the pharmacokinetic characteristics of GBE constitutes after oral GBE administration have not been established yet. In this study, stereo...

  • Article
  • Open Access
49 Citations
6,901 Views
14 Pages

A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability

  • Yejing Wang,
  • Rui Cai,
  • Gang Tao,
  • Peng Wang,
  • Hua Zuo,
  • Ping Zhao,
  • Ahmad Umar and
  • Huawei He

Silk sericin is a protein from a silkworm’s cocoon. It has good biocompatibility, hydrophilicity, bioactivity, and biodegradability. However, sericin could not be used in biomedical materials directly because of its frangible characteristic. To...

  • Article
  • Open Access
84 Citations
7,011 Views
12 Pages

Formation of Lignin Nanoparticles by Combining Organosolv Pretreatment of Birch Biomass and Homogenization Processes

  • Leonidas Matsakas,
  • Anthi Karnaouri,
  • Andrzej Cwirzen,
  • Ulrika Rova and
  • Paul Christakopoulos

Valorization of lignocellulosic biomass into a biorefinery scheme requires the use of all biomass components; in this, the lignin fraction is often underutilized. Conversion of lignin to nanoparticles is an attractive solution. Here, we investigated...

  • Article
  • Open Access
28 Citations
6,089 Views
12 Pages

Platycodi Radix (PR) is the root of Platycodon grandiflorum (Jacq.) A. DC., which has been used for a long time in China to treat pulmonary diseases. The present study aimed to evaluate the quality of PR samples collected from 23 regions of 11 provin...

  • Article
  • Open Access
25 Citations
5,516 Views
13 Pages

Whereas Korean ginseng, Panax ginseng Meyer, is harvested in the fall, the variation of ginsenoside content in field-grown ginseng across seasonal development has never been investigated in Korea. Thus, ultra-high performance liquid chromatography (U...

  • Article
  • Open Access
34 Citations
6,060 Views
11 Pages

Delivery of miRNA-Targeted Oligonucleotides in the Rat Striatum by Magnetofection with Neuromag®

  • Simoneide Souza Titze de Almeida,
  • Camila Hillesheim Horst,
  • Cristina Soto-Sánchez,
  • Eduardo Fernandez and
  • Ricardo Titze de Almeida

MicroRNAs (miRNAs) regulate gene expression at posttranscriptional level by triggering RNA interference. In such a sense, aberrant expressions of miRNAs play critical roles in the pathogenesis of many disorders, including Parkinson’s disease (P...

  • Article
  • Open Access
39 Citations
7,750 Views
17 Pages

Assessing the Antioxidant Properties of Larrea tridentata Extract as a Potential Molecular Therapy against Oxidative Stress

  • Rachid Skouta,
  • Karla Morán-Santibañez,
  • Carlos A. Valenzuela,
  • Abimael H. Vasquez and
  • Karine Fenelon

Oxidative stress has been linked to neurodegenerative diseases such as Huntington’s, Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis diseases. Larrea tridentata (LT) also known as Creosote Bush is an evergreen shrub found...

  • Article
  • Open Access
26 Citations
9,602 Views
19 Pages

Interaction between Different Pharmaceutical Excipients in Liquid Dosage Forms—Assessment of Cytotoxicity and Antimicrobial Activity

  • Dániel Nemes,
  • Renátó Kovács,
  • Fruzsina Nagy,
  • Mirtill Mező,
  • Nikolett Poczok,
  • Zoltán Ujhelyi,
  • Ágota Pető,
  • Pálma Fehér,
  • Ferenc Fenyvesi and
  • Judit Váradi
  • + 2 authors

Nowadays, the safety of parabens as pharmaceutical preservatives is debated. Recent studies investigated their interference with the oestrogen receptors, nevertheless their carcinogenic activity was also proved. That was the reason why the re-evaluat...

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Molecules - ISSN 1420-3049