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Molecules 2018, 23(7), 1823; https://doi.org/10.3390/molecules23071823

Quantitative and Chemical Fingerprint Analysis for the Quality Evaluation of Platycodi Radix Collected from Various Regions in China by HPLC Coupled with Chemometrics

1
College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
2
Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei 230038, China
3
Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei 230012, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 7 June 2018 / Revised: 14 July 2018 / Accepted: 16 July 2018 / Published: 23 July 2018
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Abstract

Platycodi Radix (PR) is the root of Platycodon grandiflorum (Jacq.) A. DC., which has been used for a long time in China to treat pulmonary diseases. The present study aimed to evaluate the quality of PR samples collected from 23 regions of 11 provinces in China. Eight saponins were quantified using HPLC coupled with evaporative light scattering detection (HPLC-ELSD). The samples with the highest total contents of saponins were from southern China, such as Yunnan, Guangxi, Jiangxi, and Guangzhou. The fingerprint analysis of PR samples was conducted by HPLC-UV method. Nineteen common peaks were selected and the similarity values varied from 0.607 to 0.921. These findings indicated that the saponins contents of PR from different regions varied significantly, with PR samples from southern China having the highest contents of saponins. These comprehensive methods were successful in evaluating the quality of PR samples from northern and southern China, which will serve as a guide for the development of PR as a clinical medication. View Full-Text
Keywords: Platycodi Radix; quality evaluation; quantitative analysis; chemical fingerprint analysis; saponin; high performance liquid chromatography (HPLC); chemometrics Platycodi Radix; quality evaluation; quantitative analysis; chemical fingerprint analysis; saponin; high performance liquid chromatography (HPLC); chemometrics
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Lu, H.; Ju, M.; Chu, S.; Xu, T.; Huang, Y.; Chan, Q.; Peng, H.; Gui, S. Quantitative and Chemical Fingerprint Analysis for the Quality Evaluation of Platycodi Radix Collected from Various Regions in China by HPLC Coupled with Chemometrics. Molecules 2018, 23, 1823.

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