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Molecules, Volume 23, Issue 2

February 2018 - 290 articles

Cover Story: Biocatalysts able to convert nitroaromatics to aromatic amines are in high demand, yet they are not commonly found in nature and only succeed for a small number of known substrates. The question therefore is “Why”? We show that substrates with large pi systems-bearing electron withdrawing groups, are more likely to form amines. Crucially, nitroreductases accommodate many such substrates. We attribute this to their intertwined architecture that supports very diverse active site shapes and sizes. This segregation of core structure vs. catalytic site, eminently suits the engineering of nitroreductases. View this paper
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Articles (290)

  • Review
  • Open Access
145 Citations
10,676 Views
11 Pages

Sulphated Flavonoids: Biosynthesis, Structures, and Biological Activities

  • Yanna C. F. Teles,
  • Maria Sallett R. Souza and
  • Maria De Fátima Vanderlei de Souza

23 February 2018

The great diversity of enzymatic reactions in plant secondary metabolism allows the continuous discovery of new natural compounds and derivatives. Flavonoids, for example, can be found as aglycone or as several sorts of glycosylated, acetylated, meth...

  • Article
  • Open Access
35 Citations
6,396 Views
15 Pages

Antioxidant Activity and Protective Effects of Enzyme-Extracted Oudemansiella radiata Polysaccharides on Alcohol-Induced Liver Injury

  • Xiuxiu Wang,
  • Min Liu,
  • Chen Zhang,
  • Shangshang Li,
  • Qihang Yang,
  • Jianjun Zhang,
  • Zhiyuan Gong,
  • Jiandong Han and
  • Le Jia

23 February 2018

This work was to examine the antioxidation in vitro and hepatoprotective effects of enzyme-extracted Oudemansiella radiata polysaccharides (En-OPS) on alcohol-induced liver damage in mice. The antioxidant activities were determined according to the s...

  • Feature Paper
  • Article
  • Open Access
77 Citations
9,552 Views
13 Pages

Antimicrobial and Antibiofilm Activity and Machine Learning Classification Analysis of Essential Oils from Different Mediterranean Plants against Pseudomonas aeruginosa

  • Marco Artini,
  • Alexandros Patsilinakos,
  • Rosanna Papa,
  • Mijat Božović,
  • Manuela Sabatino,
  • Stefania Garzoli,
  • Gianluca Vrenna,
  • Marco Tilotta,
  • Federico Pepi and
  • Rino Ragno
  • + 1 author

23 February 2018

Pseudomonas aeruginosa is a ubiquitous organism and opportunistic pathogen that can cause persistent infections due to its peculiar antibiotic resistance mechanisms and to its ability to adhere and form biofilm. The interest in the development of new...

  • Article
  • Open Access
32 Citations
6,771 Views
13 Pages

Persicaline, A New Antioxidant Sulphur-Containing Imidazoline Alkaloid from Salvadora persica Roots

  • Mohamed Farag,
  • Wael M. Abdel-Mageed,
  • Omer Basudan and
  • Ali El-Gamal

23 February 2018

Salvadora persica L. is a popular chewing stick commonly known as “miswak”. During our ongoing research activities on the chemical constituents of Salvadora persica roots, which is a new sulphur-containing imidazoline alkaloid 1,3-Dibenzyl-4-(1,2,3,4...

  • Article
  • Open Access
119 Citations
9,275 Views
15 Pages

Impact of Storage Conditions on the Stability of Predominant Phenolic Constituents and Antioxidant Activity of Dried Piper betle Extracts

  • Ameena Ali,
  • Chien Hwa Chong,
  • Siau Hui Mah,
  • Luqman Chuah Abdullah,
  • Thomas Shean Yaw Choong and
  • Bee Lin Chua

23 February 2018

The phenolic constituents in Piper betle are well known for their antioxidant potential; however, current literature has very little information on their stability under the influence of storage factors. Present study evaluated the stability of total...

  • Feature Paper
  • Article
  • Open Access
4,124 Views
7 Pages

Epitaxially Grown Ultra-Flat Self-Assembling Monolayers with Dendrimers

  • Takane Imaoka,
  • Noriko Bukeo and
  • Kimihisa Yamamoto

23 February 2018

Mono-molecular films formed by physical adsorption and dendrimer self-assembly were prepared on various substrate surfaces. It was demonstrated that a uniform dendrimer-based monolayer on the subnanometer scale can be easily constructed via simple di...

  • Article
  • Open Access
2 Citations
4,823 Views
16 Pages

Reconstructing Phylogeny by Aligning Multiple Metabolic Pathways Using Functional Module Mapping

  • Yiran Huang,
  • Cheng Zhong,
  • Hai Xiang Lin,
  • Jianyi Wang and
  • Yuzhong Peng

23 February 2018

Comparison of metabolic pathways provides a systematic way for understanding the evolutionary and phylogenetic relationships in systems biology. Although a number of phylogenetic methods have been developed, few efforts have been made to provide a un...

  • Article
  • Open Access
6 Citations
4,638 Views
9 Pages

Fast and Simple Analytical Method for Direct Determination of Total Chlorine Content in Polyglycerol by ICP-MS

  • Agata Jakóbik-Kolon,
  • Andrzej Milewski,
  • Piotr Dydo,
  • Magdalena Witczak and
  • Joanna Bok-Badura

23 February 2018

The fast and simple method for total chlorine determination in polyglycerols using low resolution inductively coupled plasma mass spectrometry (ICP-MS) without the need for additional equipment and time-consuming sample decomposition was evaluated. L...

  • Article
  • Open Access
15 Citations
4,738 Views
12 Pages

An Interaction of Rhamnolipids with Cu2+ Ions

  • Jolanta Cieśla,
  • Magdalena Koczańska and
  • Andrzej Bieganowski

23 February 2018

This study was focused on the description of interaction between Cu2+ ions and the 1:1 mono- and dirhamnolipid mixtures in the premicellar and aggregated state in water and 20 mM KCl solution at pH 5.5 and 6.0. The critical micelle concentration of b...

  • Article
  • Open Access
30 Citations
6,053 Views
13 Pages

23 February 2018

A method for daily monitoring of yttrium and rare earth elements (YREEs) in seawater using a cheap flow injection system online coupled to inductively coupled plasma-mass spectrometry is reported. Toyopearl AF Chelate 650M® resin permits separation a...

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Molecules - ISSN 1420-3049