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Review

Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights

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Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain
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Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28040 Madrid, Spain
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(1), 47; https://doi.org/10.3390/molecules23010047
Received: 10 December 2017 / Revised: 22 December 2017 / Accepted: 22 December 2017 / Published: 25 December 2017
(This article belongs to the Special Issue Mesoporous Silica in Biomedical Applications)
This manuscript reviews the recent progress on mesoporous silica nanoparticles as drug delivery systems. Their intrinsic structural, textural and chemical features permit to design versatile multifunctional nanosystems with the capability to target the diseased tissue and release the cargo on demand upon exposition to internal or external stimuli. The degradation rate of these nanocarriers in diverse physiological fluids is overviewed obeying their significance for their potential translation towards clinical applications. To conclude, the balance between the benefits and downsides of this revolutionary nanotechnological tool is also discussed. View Full-Text
Keywords: mesoporous silica nanoparticles; multifunctional nanosystem; selective targeting; stimuli-responsive drug delivery; in vitro degradation; benefits and downsides; clinical translation; biosafety mesoporous silica nanoparticles; multifunctional nanosystem; selective targeting; stimuli-responsive drug delivery; in vitro degradation; benefits and downsides; clinical translation; biosafety
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MDPI and ACS Style

Vallet-Regí, M.; Colilla, M.; Izquierdo-Barba, I.; Manzano, M. Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights. Molecules 2018, 23, 47. https://doi.org/10.3390/molecules23010047

AMA Style

Vallet-Regí M, Colilla M, Izquierdo-Barba I, Manzano M. Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights. Molecules. 2018; 23(1):47. https://doi.org/10.3390/molecules23010047

Chicago/Turabian Style

Vallet-Regí, María, Montserrat Colilla, Isabel Izquierdo-Barba, and Miguel Manzano. 2018. "Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights" Molecules 23, no. 1: 47. https://doi.org/10.3390/molecules23010047

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