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Molecules 2018, 23(1), 107; https://doi.org/10.3390/molecules23010107

Biomolecule-Functionalized Smart Polydiacetylene for Biomedical and Environmental Sensing

1
Institute for Ubiquitous Information Technology and Applications (UBITA) & Center for Biotechnology Research in UBITA (CBRU), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea
2
Department of Bioscience and Biotechnology, Microbial Carbohydrate Resource Bank (MBRC) & Center for Biotechnology Research in UBITA (CBRU), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea
*
Author to whom correspondence should be addressed.
Received: 20 November 2017 / Revised: 22 December 2017 / Accepted: 29 December 2017 / Published: 4 January 2018
(This article belongs to the Section Analytical Chemistry)
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Abstract

Polydiacetylene (PDA) has attracted interest for use as a sensing platform in biomedical, environmental, and chemical engineering applications owing to its capacity for colorimetric and fluorescent transition in response to external stimuli. Many researchers have attempted to develop a tailor-made PDA sensor via conjugation of chemical or biological substances to PDA. Here, we review smart bio-conjugates of PDA with various biomolecules such as carbohydrates, lipids, nucleic acids, and proteins. In addition, materialization and signal amplification strategies to improve handling and sensitivity are described. View Full-Text
Keywords: biomolecules; polydiacetylene; conjugation; sensor biomolecules; polydiacetylene; conjugation; sensor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Cho, E.; Jung, S. Biomolecule-Functionalized Smart Polydiacetylene for Biomedical and Environmental Sensing. Molecules 2018, 23, 107.

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