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Comment published on 19 July 2017, see Molecules 2017, 22(7), 1216.
Open AccessHypothesis

Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer

Cytoregulation Research, Elgin, ON K0G1E0, Canada
Academic Editors: Noriyuki Nagahara and Maria Wrobel
Molecules 2017, 22(4), 582; https://doi.org/10.3390/molecules22040582
Received: 6 February 2017 / Revised: 22 March 2017 / Accepted: 30 March 2017 / Published: 5 April 2017
(This article belongs to the Special Issue Sulfur Atom: Element for Adaptation to an Oxidative Environment 2016)
Evidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B12-dependent methyl group transfer. To compile the evidence, it is necessary to briefly review the following fields: methylation, the new field of sulfane sulfur/hydrogen sulfide (S°/H2S), hydrosulfide derivatives of cobalamins, autoxidation of hydrosulfide radical, radical S-adenosylmethionine methyl transfer (RSMT), and methionine synthase (MS). Then, new reaction mechanisms for B12-dependent methyl group transfer are proposed; the mechanisms are facile and overcome difficulties that existed in previously-accepted mechanisms. Finally, the theory is applied to the effect of S°/H2S in nerve tissue involving the “hypomethylation theory” that was proposed 50 years ago to explain the neuropathology resulting from deficiency of vitamin B12 or folic acid. The conclusions are consistent with emerging evidence that sulfane sulfur/hydrogen sulfide may be beneficial in treating Alzheimer’s disease. View Full-Text
Keywords: sulfane sulfur; hydrogen sulfide; methylation; radical S-adenosylmethionine methyl transferases; methionine synthase; cobalamin; viscose dialysis tubing; methionine auxotrophy; hypomethylation; dementia; Alzheimer’s disease sulfane sulfur; hydrogen sulfide; methylation; radical S-adenosylmethionine methyl transferases; methionine synthase; cobalamin; viscose dialysis tubing; methionine auxotrophy; hypomethylation; dementia; Alzheimer’s disease
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MDPI and ACS Style

Toohey, J.I. Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer. Molecules 2017, 22, 582. https://doi.org/10.3390/molecules22040582

AMA Style

Toohey JI. Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer. Molecules. 2017; 22(4):582. https://doi.org/10.3390/molecules22040582

Chicago/Turabian Style

Toohey, John I. 2017. "Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer" Molecules 22, no. 4: 582. https://doi.org/10.3390/molecules22040582

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