Next Article in Journal
Synthesis of Some New Pyridazine Derivatives for Anti-HAV Evaluation
Previous Article in Journal
New Frontiers on the Metabolism, Bioavailability and Health Effects of Phenolic Compounds
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(1), 147;

Synthesis and Biotransformation of Bicyclic Unsaturated Lactones with Three or Four Methyl Groups

Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland
Faculty of Chemistry, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland
Institute of General Food Chemistry, Lodz University of Technology, Stefanowskiego 4/10, 90-924 Łódź, Poland
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 21 November 2016 / Revised: 4 January 2017 / Accepted: 11 January 2017 / Published: 17 January 2017
Full-Text   |   PDF [2230 KB, uploaded 17 January 2017]   |  


The aim of this study was to obtain new unsaturated lactones by chemical synthesis and their microbial transformations using fungal strains. Some of these strains were able to transform unsaturated lactones into different hydroxy or epoxy derivatives. Strains of Syncephalastrum racemosum and Absidia cylindrospora gave products with a hydroxy group introduced into a tertiary carbon, while the Penicillium vermiculatum strain hydroxylated primary carbons. The Syncephalastrum racemosum strain hydroxylated both substrates in an allylic position. Using the Absidia cylindrospora and Penicillium vermiculatum strains led to the obtained epoxylactones. The structures of all lactones were established on the basis of spectroscopic data. View Full-Text
Keywords: unsaturated lactones; hydroxylation; epoxidation; biotransformation unsaturated lactones; hydroxylation; epoxidation; biotransformation

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Wińska, K.; Grabarczyk, M.; Mączka, W.; Kondas, A.; Maciejewska, G.; Bonikowski, R.; Anioł, M. Synthesis and Biotransformation of Bicyclic Unsaturated Lactones with Three or Four Methyl Groups. Molecules 2017, 22, 147.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top