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Molecules 2016, 21(2), 238;

Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles

Department of Chemistry, National Changhua University of Education, Changhua 50007, Taiwan
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 27 January 2016 / Revised: 13 February 2016 / Accepted: 15 February 2016 / Published: 19 February 2016
(This article belongs to the Section Organic Chemistry)
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A procedure has been developed for synthesis of 2-alkenyl-2H-indazoles starting from 2-(2-carbonylmethyl)-2H-indazoles, which are prepared by gallium/aluminium- and aluminium-mediated, direct, regioselective alkylation of indazoles with α-bromocarbonyl compounds. The structure of 3-(2H-indazol-2-yl)-2H-chromen-2-one was proven by X-ray crystallography. The styrene- and coumarin-2H-indazoles produced by using the new method were found to have interesting fluorescence properties. View Full-Text
Keywords: indazoles; coumarin; regioselective alkylation; styrene; fluorescence indazoles; coumarin; regioselective alkylation; styrene; fluorescence

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Lin, M.-H.; Liang, K.-Y.; Tsai, C.-H.; Chen, Y.-C.; Hsiao, H.-C.; Li, Y.-S.; Chen, C.-H.; Wu, H.-C. Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles. Molecules 2016, 21, 238.

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