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Open AccessArticle

Bioactivities of a New Pyrrolidine Alkaloid from the Root Barks of Orixa japonica

1
Department of Entomology, China Agricultural University, Haidian District, Beijing 100193, China
2
Department of Plant Pathology, China Agricultural University, Haidian District, Beijing 100193, China
3
State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center of Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
*
Author to whom correspondence should be addressed.
Academic Editor: Michael Wink
Molecules 2016, 21(12), 1665; https://doi.org/10.3390/molecules21121665
Received: 26 October 2016 / Revised: 23 November 2016 / Accepted: 29 November 2016 / Published: 2 December 2016
(This article belongs to the Special Issue Diversity of Alkaloids)
A new pyrrolidine alkaloid named (Z)-3-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)-1-methylpyrrolidin-2-one was isolated from the ethanol extract of the root barks of Orixa japonica. The structure of the new alkaloid was elucidated on the basis of NMR and MS analysis. The compound exhibited larvicidal activity against the fourth instar larvae of Aedes aegypti (LC50 = 232.09 μg/mL), Anopheles sinensis (LC50 = 49.91 μg/mL), and Culex pipiens pallens (LC50 = 161.10 μg/mL). The new alkaloid also possessed nematicidal activity against Bursaphelenchus xylophilus (LC50 = 391.50 μg/mL) and Meloidogynein congnita (LC50 = 134.51 μg/mL). The results indicate that the crude ethanol extract of O. japonica root barks and its isolated pyrrolidine alkaloid have potential for development into natural larvicides and nematicides. View Full-Text
Keywords: Orixa japonica; mosquito; pyrrolidine alkaloid; larvicidal activity; nematicidal activity Orixa japonica; mosquito; pyrrolidine alkaloid; larvicidal activity; nematicidal activity
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MDPI and ACS Style

Liu, X.C.; Lai, D.; Liu, Q.Z.; Zhou, L.; Liu, Q.; Liu, Z.L. Bioactivities of a New Pyrrolidine Alkaloid from the Root Barks of Orixa japonica. Molecules 2016, 21, 1665.

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