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Open AccessCommunication

Guignardones P–S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra

1
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China
2
School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China
*
Author to whom correspondence should be addressed.
Academic Editors: John A. Beutler and Derek J. McPhee
Molecules 2015, 20(12), 22900-22907; https://doi.org/10.3390/molecules201219890
Received: 23 November 2015 / Revised: 15 December 2015 / Accepted: 17 December 2015 / Published: 21 December 2015
(This article belongs to the Collection Bioactive Compounds)
Four new meroterpenoids, guignardones P–S (14), and three known analogues (57) were isolated from the endophytic fungal strain Guignardia mangiferae A348. Their structures were elucidated on the basis of spectroscopic analysis and single crystal X-ray diffraction. All the isolated compounds were evaluated for their inhibitory effects on SF-268, MCF-7, and NCI-H460 human cancer cell lines. Compounds 2 and 4 exhibited weak inhibitions of cell proliferation against MCF-7 cell line. View Full-Text
Keywords: Guignardia mangiferae; meroterpenoids; structure identification; Smilax glabra; endophytic fungus Guignardia mangiferae; meroterpenoids; structure identification; Smilax glabra; endophytic fungus
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Sun, Z.-H.; Liang, F.-L.; Wu, W.; Chen, Y.-C.; Pan, Q.-L.; Li, H.-H.; Ye, W.; Liu, H.-X.; Li, S.-N.; Tan, G.-H.; Zhang, W.-M. Guignardones P–S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra. Molecules 2015, 20, 22900-22907.

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