Next Article in Journal
Combined Effects of Ultrasound and Immobilization Protocol on Butyl Acetate Synthesis Catalyzed by CALB
Next Article in Special Issue
Batch and Continuous Flow Preparation of Hantzsch 1,4-Dihydropyridines under Microwave Heating and Simultaneous Real-time Monitoring by Raman Spectroscopy. An Exploratory Study
Previous Article in Journal
Secondary Metabolite Profiling of Curcuma Species Grown at Different Locations Using GC/TOF and UPLC/Q-TOF MS
Previous Article in Special Issue
New Potentially Active Pyrazinamide Derivatives Synthesized Under Microwave Conditions
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(7), 9552-9561;

Formation of a Flavin-Linked Peptide

Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan
Author to whom correspondence should be addressed.
Received: 27 May 2014 / Revised: 2 July 2014 / Accepted: 2 July 2014 / Published: 4 July 2014
(This article belongs to the Special Issue ECSOC-17)
Full-Text   |   PDF [501 KB, uploaded 4 July 2014]   |  


In a previous study, we showed that formylmethylflavin (FMF) can bind to cysteine. In this study, FMF was reacted with native peptides (CG and CKLVFF) containing an N-terminal cysteine. The formation of flavin-CG and flavin-CKLVFF was confirmed using HPLC and ESI-MS. Storage of flavin-CKLVFF in DMSO at −30 °C for 7 days resulted in no detectable deposition. In contrast, flavin-CKLVFF formed deposits when stored in water at −30 °C for 1 day, but no deposit was observed in the aqueous solution of flavin-CKLVFF after 7 days storage in the presence of 0.1% Triton X-100. View Full-Text
Keywords: flavin; peptide; cysteine; aldehyde; Aβ peptide flavin; peptide; cysteine; aldehyde; Aβ peptide

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Morikawa, M.; Kino, K.; Senda, T.; Suzuki, M.; Kobayashi, T.; Miyazawa, H. Formation of a Flavin-Linked Peptide. Molecules 2014, 19, 9552-9561.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top