Increased Circulating MicroRNA-155 as a Potential Biomarker for Breast Cancer Screening: A Meta-Analysis
Abstract
:1. Introduction
2. Results
2.1. Characteristics of Included Studies
Authors [ref] | Year | Patients (Control) | QUADAS Scores | Stage I, II% | Mean Age | AUC | Endogenous Control | Cut-off | Sen% | Spe% |
---|---|---|---|---|---|---|---|---|---|---|
Zhao et al. [20] | 2012 | 20(10) | 12 | 100 | 53 | 0.97 | RNU6B | 0.95 | 100 | 90 |
Sun et al. [17] | 2012 | 103(55) | 13 | 63.1 | 51 | 0.801 | cel-mir-39 | 1.911 | 65.0 | 81.8 |
Mar-Aguilar et al. [18] | 2013 | 61(10) | 12 | 44.3 | 53 | 0.9944 | 18S RNA | 7.92 | 94.40 | 100.00 |
2.2. Quality of Included Studies
2.3. Description of Outcomes
2.4. Data Analysis
2.4.1. Sensitivity and Specificity
2.4.2. Positive LR and Negative LR
2.4.3. SROC and DOR
2.5. Publication Bias
2.6. Threshold Effect
3. Discussion
4. Materials and Methods
4.1. Search Strategy
4.2. Eligibility Criteria
4.3. Data Abstraction
4.4. Quality Assessment
4.5. Statistical Analysis
5. Conclusions
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Share and Cite
Wang, F.; Hou, J.; Jin, W.; Li, J.; Yue, Y.; Jin, H.; Wang, X. Increased Circulating MicroRNA-155 as a Potential Biomarker for Breast Cancer Screening: A Meta-Analysis. Molecules 2014, 19, 6282-6293. https://doi.org/10.3390/molecules19056282
Wang F, Hou J, Jin W, Li J, Yue Y, Jin H, Wang X. Increased Circulating MicroRNA-155 as a Potential Biomarker for Breast Cancer Screening: A Meta-Analysis. Molecules. 2014; 19(5):6282-6293. https://doi.org/10.3390/molecules19056282
Chicago/Turabian StyleWang, Faliang, Jinchao Hou, Wei Jin, Jiaqiu Li, Yongfang Yue, Hongchuan Jin, and Xian Wang. 2014. "Increased Circulating MicroRNA-155 as a Potential Biomarker for Breast Cancer Screening: A Meta-Analysis" Molecules 19, no. 5: 6282-6293. https://doi.org/10.3390/molecules19056282