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Open AccessArticle

New Biscoumarin Derivatives: Synthesis, Crystal Structure, Theoretical Study and Antibacterial Activity against Staphylococcus aureus

by Di Qu 1,†, Jing Li 2,†, Xiao-Hui Yang 2, Zi-Dan Zhang 3, Xiao-Xing Luo 1, Ming-Kai Li 1,* and Xia Li 4,*
1
Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi'an 710032, China
2
School of Chemistry and Chemical Engineering, Xi'an University, Xi'an 710065, China
3
Department of Physics, School of Science, Tianjin University, Tianjin 300072, China
4
Department of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2014, 19(12), 19868-19879; https://doi.org/10.3390/molecules191219868
Received: 24 July 2014 / Revised: 23 October 2014 / Accepted: 29 October 2014 / Published: 28 November 2014
(This article belongs to the Section Medicinal Chemistry)
Five novel biscoumarins 15 were synthesized and characterized. In these compounds, two classical asymmetrical intramolecular O–H···O hydrogen bonds were used to stabilize the whole structures and the HB energies were performed with the density functional theory (DFT) [B3LYP/6-31G*] method. The five compounds were evaluated for their in vitro antibacterial activities against Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone, LAC) by the means of minimum inhibitory concentration and time-kill curves. View Full-Text
Keywords: biscoumarin; Staphylococcus aureus; minimum inhibitory concentration biscoumarin; Staphylococcus aureus; minimum inhibitory concentration
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MDPI and ACS Style

Qu, D.; Li, J.; Yang, X.-H.; Zhang, Z.-D.; Luo, X.-X.; Li, M.-K.; Li, X. New Biscoumarin Derivatives: Synthesis, Crystal Structure, Theoretical Study and Antibacterial Activity against Staphylococcus aureus. Molecules 2014, 19, 19868-19879.

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