Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production

Matsui, Yuuki; Kikuchi, Takashi; Inoue, Takanobu; Muraoka, Osamu; Yamada, Takeshi; Tanaka, Reiko

doi:10.3390/molecules191117130

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Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production

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Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan

Faculty of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashiosaka, Osaka 577-8502, Japan

Author to whom correspondence should be addressed.

Molecules 2014, 19(11), 17130-17140; https://doi.org/10.3390/molecules191117130

Received: 5 September 2014 / Revised: 17 October 2014 / Accepted: 20 October 2014 / Published: 24 October 2014

(This article belongs to the Collection Bioactive Compounds)

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Abstract

A novel gedunin and two novel phragmalin-type limonoids, named carapanolides J–L (compounds 1–3) as well as a known gedunin-type limonoid 4 were isolated from the seeds of Carapa guianensis (andiroba). Their structures were determined on the basis of 1D and 2D NMR spectroscopy and HRFABMS. Compounds 1–4 were evaluated for their effects on the production of NO in LPS-activated mouse peritoneal macrophages. View Full-Text

Keywords: Carapa guianensis; andiroba; seeds; gedunin; phragmalin; limonoids; NO production

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Matsui, Y.; Kikuchi, T.; Inoue, T.; Muraoka, O.; Yamada, T.; Tanaka, R. Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production. Molecules 2014, 19, 17130-17140. https://doi.org/10.3390/molecules191117130

AMA Style

Matsui Y, Kikuchi T, Inoue T, Muraoka O, Yamada T, Tanaka R. Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production. Molecules. 2014; 19(11):17130-17140. https://doi.org/10.3390/molecules191117130

Chicago/Turabian Style

Matsui, Yuuki, Takashi Kikuchi, Takanobu Inoue, Osamu Muraoka, Takeshi Yamada, and Reiko Tanaka. 2014. "Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production" Molecules 19, no. 11: 17130-17140. https://doi.org/10.3390/molecules191117130

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Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production

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