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Molecules, Volume 17, Issue 3

March 2012 - 84 articles

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Articles (84)

  • Article
  • Open Access
8 Citations
6,096 Views
14 Pages

22 March 2012

In view of the growing demand for new compounds showing biological activity against pathogenic microorganisms, such as pathogenic and phytopathogenic fungi, the objective of this study was to synthesize a new group of aliphatic and aromatic derivativ...

  • Article
  • Open Access
100 Citations
9,032 Views
12 Pages

Regulation of Inflammatory Cytokines in Lipopolysaccharide-Stimulated RAW 264.7 Murine Macrophage by 7-O-Methyl-naringenin

  • Lanan Wassy Soromou,
  • Zhichao Zhang,
  • Rongtao Li,
  • Na Chen,
  • Weixiao Guo,
  • Meixia Huo,
  • Shuang Guan,
  • Jing Lu and
  • Xuming Deng

22 March 2012

7-O-Methylnaringenin, extracted from Rhododendron speciferum, belongs to the flavanone class of polyphenols. In the present study, we investigated the anti-inflammatory effects of 7-O-methylnaringenin on cytokine production by lipopoly-saccharide (LP...

  • Article
  • Open Access
108 Citations
9,499 Views
13 Pages

Effects of a Natural Prolyl Oligopeptidase Inhibitor, Rosmarinic Acid, on Lipopolysaccharide-Induced Acute Lung Injury in Mice

  • Xiao Chu,
  • Xinxin Ci,
  • Jiakang He,
  • Lanxiang Jiang,
  • Miaomiao Wei,
  • Qingjun Cao,
  • Mingfeng Guan,
  • Xianxing Xie,
  • Xuming Deng and
  • Jiakang He

22 March 2012

Rosmarinic acid (RA), a polyphenolic phytochemical, is a natural prolyl oligopeptidase inhibitor. In the present study, we found that RA exerted potent anti-inflammatory effects in in vivo models of acute lung injury (ALI) induced by lipopolysacchari...

  • Article
  • Open Access
47 Citations
11,368 Views
13 Pages

Acute Toxicity Evaluation, Antibacterial, Antioxidant and Immunomodulatory Effects of Melastoma malabathricum

  • Zahra A. Amin Alnajar,
  • Mahmood A. Abdulla,
  • Hapipah M. Ali,
  • Mohammed A. Alshawsh and
  • A. Hamid A. Hadi

20 March 2012

Melastoma malabathricum (MM) is a well-known plant in Malaysian traditional medicine, locally known as senduduk. Its ethanol and aqueous extracts have been used in the present investigation to study the immunomodulatory role on human peripheral blood...

  • Article
  • Open Access
19 Citations
6,478 Views
9 Pages

19 March 2012

As part of our project devoted to the synthesis of heterocycles including thiazole rings, some new 5-arylidene-2-thioxo-3-N-arylthiazolidin-4-ones were synthesized by Knoevenagel condensation. An interesting feature of these compounds is that their c...

  • Article
  • Open Access
29 Citations
6,724 Views
14 Pages

19 March 2012

In present study, the performance and separation characteristics of 21 macroporous resins for the enrichment and purification of deoxyschizandrin and γ-schizandrin, the two major lignans from Schisandra chinensis extracts, were evaluated. According t...

  • Review
  • Open Access
131 Citations
17,217 Views
15 Pages

19 March 2012

Alzheimer’s disease (AD) is one of the most well-known neurodegenerative diseases and explains 50–60% of dementia in patients. The prevalence rate of AD is positively correlated with age and AD affects ≥ 40% of those over 85 years old. The major AD t...

  • Article
  • Open Access
47 Citations
8,110 Views
8 Pages

A New Norisoprenoid and Other Compounds from Fuzhuan Brick Tea

  • Zhen-Mei Luo,
  • Tie-Jun Ling,
  • Li-Xiang Li,
  • Zheng-Zhu Zhang,
  • Hong-Tao Zhu,
  • Ying-Jun Zhang and
  • Xiao-Chun Wan

19 March 2012

Fuzhuan brick tea, a kind of dark tea consumed mainly in the border regions of Southwestern and Northwestern China since the 1860s, is produced from the leaves of Camellia sinensis var. sinensis by microbial fermentation. From this special fermented...

  • Article
  • Open Access
38 Citations
9,315 Views
14 Pages

Simultaneous Analysis of Irbesartan and Hydrochlorothiazide: An Improved HPLC Method with the Aid of a Chemometric Protocol

  • Zorica Vujić,
  • Nedžad Mulavdić,
  • Miralem Smajić,
  • Jasmina Brborić and
  • Predrag Stankovic

16 March 2012

Experimental design method was used for HPLC determination of irbesartan and hydrochlorothiazide in combined dosage forms. The traditional approach for optimization of experiments is time-consuming, involves a large number of runs and does not allow...

  • Article
  • Open Access
27 Citations
6,175 Views
9 Pages

16 March 2012

The reaction of adamantane-1-carbohydrazide (1) with heterocyclic aldehydes, namely 5-(4-chlorophenyl)isoxazole-3-carboxaldehyde (2a), 5-(4-methylphenyl)isoxazole-3-carboxaldehyde (2b), 5-(4-methoxyphenyl)isoxazole-3-carboxaldehyde (2c), 1H-imidazole...

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Molecules - ISSN 1420-3049