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Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties

Department of Chemistry, Yonsei University, Seoul 120-749, Korea
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Molecules 2011, 16(12), 9886-9899; https://doi.org/10.3390/molecules16129886
Received: 1 November 2011 / Revised: 18 November 2011 / Accepted: 22 November 2011 / Published: 28 November 2011
(This article belongs to the Section Organic Chemistry)
Dimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for biological application was evaluated by UV and fluorescence to determine its electrochemical absorption and emission properties. This probe could be valuable for investigating ligand-protein interactions and subcellular localization. View Full-Text
Keywords: dimethyl lithospermate B; target identification; photochemical and fluorescent probe; dual probe dimethyl lithospermate B; target identification; photochemical and fluorescent probe; dual probe
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Lim, E.; Ricci, J.; Jung, M. Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties. Molecules 2011, 16, 9886-9899.

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