Molecules, Volume 13, Issue 4

The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been madeaccessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclicbenzofuranones 2 and 3, respectively. A four-step synthesis to spirocompound 4 isd...

The epimeric sesquiterpene alcohols (14R)-β-oplopenol and (14S)-β-oplopenolwere obtained by LiAlH₄ reduction of β-oplopenone. The complete ¹H- and ¹³C-NMRassignments of these two new sesquiterpene alcohols have been made using 1D and 2DNMR techniques...

Several 1,3-diaryl-5-(cyano-, aminocarbonyl- and ethoxycarbonyl-)-2-pyrazoline, pyrrolo[3,4-c]pyrazole-4,6-dione and 1,3,4,5-tetraaryl-2-pyrazoline derivativeswere prepared by the reaction of nitrilimine with different dipolarophilic reagents. The ne...

A series of fluorinated analogs of malachite green (MG) have been synthesizedand their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell lineexamined. The toxicity profiles were found to be different for these two species. Twoa...

A solvent-free approach for the regioselective synthesis of β-amino alcohols inshorter reaction times and higher yields, compared to conventional heating is described. Itinvolves microwave (MW) exposure of undiluted reactants in the presence of sulph...

Two substituted quinazolinyl/imidazolyl-salicylic acids 5, 6 were synthesized bythe reaction of 6-iodo-2-methylbenzoxazin-4-one/5-nitroimidazole with 5-aminosalicylicacid (5-ASA). Coupling of compounds 5 and 6 with different amino acid esterhydrochlo...

4-Methyl-5-formylthiazole, an intermediate for synthesizing cefditoren pivoxil,was prepared in good yield by Pd/BaSO₄ catalyzed hydrogenation of 4-methylthiazole-5-carboxylic acid chloride. Detailed reaction conditions have been studied.

Furfural was oxidized to furoic acid by molecular oxygen under catalysis by 150nm-sized Ag₂O/CuO (92%) or simply CuO (86.6%). When 30 nm-size catalyst was used,the main product was a furfural Diels-Alder adduct. Detailed reaction conditions andregene...

A series of dendritic 8-hydroxyquinoline (8-HQ) and 5-dialkyl(aryl)aminomethyl-8-HQ derivatives were synthesized and their fluoroionophoric properties towardrepresentative alkali, alkaline earth, group IIIA and transition metal ions wereinvestigated...

Two new monoterpenoid coumarins: anisucumarin A (1) and B (2), a pair ofepimers, were isolated from Clausena anisum-olens. Their structures were establishedbased on extensive spectroscopic analyses.

The conversion from kobophenol A into carasinol B, two main chemicalconstituents of Caragana sinica, was confirmed by in vitro acid-catalyzed epimerization.The result provides important information about the biotransformation of kobophenol A inplants...

Curative radiation therapy of pelvic malignancies, frequently results in doselimitingtoxicities such as serous, mucoid, or more rarely, bloody diarrhea. Several studieshave evaluated the cytoprotective effects of amifostine in preventing rectal mucos...

Hydnophytum formicarum Jack. (Rubiaceae) is a medicinal plant whose tuberspossesses cardiovascular, anti-inflammatory and antiparasitic effects and have been usedfor the treatment of hepatitis, rheumatism and diarrhea. Herein we report the isolation...

The haptens 4-[[(2,3-dihydro-2,2-dimethyl-7-benzofuranyloxy)carbonyl]-amino]butanoic acid (BFNB) and 6-[((2,3-dihydro-2,2-dimethyl-7-benzofuranyloxy)-carbonylamino]hexanoic acid (BFNH) were synthesized and then used to develop a rapid,specific and se...

An analysis of the antibacterial activities of 15 terpenoids, eleven of which werepreviously described by us and four were extracted from the literature, suggested twostructural requirements for activity of these and related compounds: a hydrophobic...

The nervous and immune systems of invertebrates can exchange informationthrough neuropeptides. Furthermore, some opioid peptides can function as endogenousimmune system messengers and participate in the regulation of the immune responses. Thepresent...

The design and synthesis of 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-thioaceto-(2-fluorobenzyl) hydrazone (TPTH), which self-assembled into supramolecularmicrofibers with blue organic light-emitting properties, is reported. This is the firstocc...

We present herein the results of microwave promoted N-alkylations of isatin (1)with different alkyl, benzyl and functionalized alkyl halides. Reactions were carried outunder different conditions, always employing methodologies compatible with MW assi...

We report the synthesis and total NMR characterization of 5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid-3-[[[(4’’-nitrophenoxy)carbonyl]oxy]-methyl]-8-oxo-7-[(2-thienyloxoacetyl)amino]-diphenylmethyl ester-5-dioxide (5), a new cephalosporind...

New N-aryl-4-(pyridin-3-yl)pyrimidin-2-amine derivatives were synthesizedfrom the corresponding amines, applying optimized Buchwald-Hartwig aminationconditions using dichlorobis(triphenylphosphine)Pd(II), xantphos and sodium tertbutoxidein refluxing...

We describe the synthesis and characterization of two new zinc (II) andcadmium (II) complexes of the tetradentate dissymmetric Schiff base ligand 2-((E)-(2-(2-(pyridine-2-yl)ethylthio)ethylimino)methyl)-4-bromophenol (PytBrsalH), prepared from 1-(2-p...

The essential oils of the aerial parts of Kundmannia sicula (L.) DC collectedfrom two Algerian localities, El Kala (near the coast) and Béjaia (from a meadow about 10km from the coast), were analysed by GC and GC-MS. Although both samples showedsimil...

The essential oil of Helichrysum italicum (Roth) G. Don (everlasting orImmortelle essential oil) was isolated by hydrodistillation and analysed by GC and GCMS.Forty four compounds were identified. The main components were α-pinene(12.8%), 2-methyl-cy...

The antimicrobial activities of aqueous ethanol and chloroform extracts of threeBaccharis species currently used in Northern Chile folk medicine for the treatment ofseveral infectious and inflammatory disorders were tested against Gram-positive andne...

We have investigated a microwave–assisted synthesis of 4(3H)–quinazolinonesby condensation of anthranilic acid, orthoesters (or formic acid) and substituted anilines,using Keggin-type heteropolyacids (H₃PW₁₂O₄₀·13H₂O, H₄SiW₁₂O₄₀·13H₂O,H₄SiMo₁₂O₄₀·13H...

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During the course of our continuing studies on marine natural lipid products,two known sphingolipids have been isolated for the first time from a specimen of themarine sponge Oceanapia ramsayi collected at Itampolo on the west coast of Madagascarin t...

We report the synthesis, antioxidant and antiproliferative activity and a QSARanalysis of synthetic diphenylpropionamide derivatives. Synthesis of these compounds wasachieved by direct condensation of 2,2- and 3,3-diphenylpropionic acid and appropria...

Novel unsaturated ethers were synthesised in good yields starting from sucrose,using a two-step mild and efficient procedure based on the Gassman method, whichconsists in forming a vinyl group by the elimination of ethanol from mixed acetals withtrim...

Addition of carboxylic acid dianions to bromoacetonitrile lead, in good yields,to the corresponding γ-cyanoacids, which on hydrogenation yielded γ-aminoacids. Thistwo step methodology improves upon previously described results. Poor e.e’s resultedfro...

From the underground parts of Picrorhiza scrophulariiflora, three new caffeoylglycosides, scrocaffeside A-C (1-3), together with two caffeic acid derivates, 4-O-β-Dglucopyranosylcaffeic acid (4) and 4-methoxycaffeic acid (5) and a phenylethanoidglyco...

We have synthesized twelve 2-substituted benzimidazole, benzothiazole andindole derivatives using on both microwave irradiation and conventional heating methods.The microwave method was observed to be more beneficial as it provides an increase ofyiel...