Table of Contents
Entropy, Volume 21, Issue 7 (July 2019) – 95 articles
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Cover Story (view full-size image) This perspective discusses parallels between high entropy at individual sequence positions of [...] Read more. This perspective discusses parallels between high entropy at individual sequence positions of intrinsically disordered proteins and regions (IDRs) and the diversity of their dynamically sampled conformations. Arguments are put forth for abandoning the approach of deriving information from the positional sequence conservation of IDRs, due to its reliance on sequence–structure–function relationships. A recent method that relies instead on the evolutionary conservation of molecular features is proposed for elucidating IDR information content. Experimental and theoretical approaches for approximating IDR conformational entropy are reviewed, focusing on changes in conformational entropy and other biophysical features of IDRs upon biomolecular interactions, post-translational modifications, and liquid–liquid phase separation. View this paper.