Next Article in Journal
Integrative Analysis of miRNA and mRNA Expression Profiles in Mammary Glands of Holstein Cows Artificially Infected with Staphylococcus aureus
Previous Article in Journal
Drift of the Subgingival Periodontal Microbiome during Chronic Periodontitis in Type 2 Diabetes Mellitus Patients
Previous Article in Special Issue
Functional Autoreactive Anti-β2 Adrenergic Antibodies May Contribute to Insulin Resistance Profile in Patients with Chronic Chagas Disease
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pathogens
Volume 10
Issue 5
10.3390/pathogens10050505
pathogens-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Chagas Cardiomyopathy: From Romaña Sign to Heart Failure and Sudden Cardiac Death

by
Antonia Pino-Marín
1,*,
Germán José Medina-Rincón
1,
Sebastian Gallo-Bernal
1,2,
Alejandro Duran-Crane
3,
Álvaro Ignacio Arango Duque
4,
María Juliana Rodríguez
1,2,
Ramón Medina-Mur
2,
Frida T. Manrique
2,
Julian F. Forero
1,5 and
Hector M. Medina
1,2
1
School of Medicine and Health Sciences, Universidad del Rosario, Bogotá 110131, Colombia
2
Division of Cardiology, Fundación Cardio-Infantil-Instituto de Cardiología, Bogotá 110131, Colombia
3
Internal Medicine Residency Program, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
4
Department of Infectious Diseases, Fundación Cardio-Infantil-Instituto de Cardiología, Bogotá 110131, Colombia
5
Division of Radiology, Fundación Cardio-Infantil-Instituto de Cardiología, Bogotá 110131, Colombia
*
Author to whom correspondence should be addressed.
Pathogens 2021, 10(5), 505; https://doi.org/10.3390/pathogens10050505
Submission received: 19 March 2021 / Revised: 10 April 2021 / Accepted: 13 April 2021 / Published: 22 April 2021
(This article belongs to the Special Issue Metabolic Dysfunction in Chagas Cardiomyopathy)
Browse Figures
Versions Notes

Abstract

Despite nearly a century of research and accounting for the highest disease burden of any parasitic disease in the Western Hemisphere, Chagas disease (CD) is still a challenging diagnosis, primarily due to its poor recognition outside of Latin America. Although initially considered endemic to Central and South America, globalization, urbanization, and increased migration have spread the disease worldwide in the last few years, making it a significant public health threat. The international medical community’s apparent lack of interest in this disease that was previously thought to be geographically restricted has delayed research on the complex host–parasite relationship that determines myocardial involvement and its differential behavior from other forms of cardiomyopathy, particularly regarding treatment strategies. Multiple cellular and molecular mechanisms that contribute to degenerative, inflammatory, and fibrotic myocardial responses have been identified and warrant further research to expand the therapeutic arsenal and impact the high burden attributed to CD. Altogether, cardiac dysautonomia, microvascular disturbances, parasite-mediated myocardial damage, and chronic immune-mediated injury are responsible for the disease’s clinical manifestations, ranging from asymptomatic disease to severe cardiac and gastrointestinal involvement. It is crucial for healthcare workers to better understand CD transmission and disease dynamics, including its behavior on both its acute and chronic phases, to make adequate and evidence-based decisions regarding the disease. This review aims to summarize the most recent information on the epidemiology, pathogenesis, clinical presentation, diagnosis, screening, and treatment of CD, emphasizing on Chagasic cardiomyopathy’s (Ch-CMP) clinical presentation and pathobiological mechanisms leading to sudden cardiac death.
Keywords: Ch-CMP/Chagas cardiomyopathy; Chagas disease; trypanosoma; heart failure; sudden cardiac death Ch-CMP/Chagas cardiomyopathy; Chagas disease; trypanosoma; heart failure; sudden cardiac death

Share and Cite

MDPI and ACS Style

Pino-Marín, A.; Medina-Rincón, G.J.; Gallo-Bernal, S.; Duran-Crane, A.; Arango Duque, Á.I.; Rodríguez, M.J.; Medina-Mur, R.; Manrique, F.T.; Forero, J.F.; Medina, H.M. Chagas Cardiomyopathy: From Romaña Sign to Heart Failure and Sudden Cardiac Death. Pathogens 2021, 10, 505. https://doi.org/10.3390/pathogens10050505

AMA Style

Pino-Marín A, Medina-Rincón GJ, Gallo-Bernal S, Duran-Crane A, Arango Duque ÁI, Rodríguez MJ, Medina-Mur R, Manrique FT, Forero JF, Medina HM. Chagas Cardiomyopathy: From Romaña Sign to Heart Failure and Sudden Cardiac Death. Pathogens. 2021; 10(5):505. https://doi.org/10.3390/pathogens10050505

Chicago/Turabian Style

Pino-Marín, Antonia, Germán José Medina-Rincón, Sebastian Gallo-Bernal, Alejandro Duran-Crane, Álvaro Ignacio Arango Duque, María Juliana Rodríguez, Ramón Medina-Mur, Frida T. Manrique, Julian F. Forero, and Hector M. Medina. 2021. "Chagas Cardiomyopathy: From Romaña Sign to Heart Failure and Sudden Cardiac Death" Pathogens 10, no. 5: 505. https://doi.org/10.3390/pathogens10050505

APA Style

Pino-Marín, A., Medina-Rincón, G. J., Gallo-Bernal, S., Duran-Crane, A., Arango Duque, Á. I., Rodríguez, M. J., Medina-Mur, R., Manrique, F. T., Forero, J. F., & Medina, H. M. (2021). Chagas Cardiomyopathy: From Romaña Sign to Heart Failure and Sudden Cardiac Death. Pathogens, 10(5), 505. https://doi.org/10.3390/pathogens10050505

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop