Targeting Novel Anticancer Agents: From Molecular Mechanisms and Tumor Microenvironment to Therapy Resistance

Dear Colleagues,

This Topic focuses on the latest advances in the development of novel anticancer agents, highlighting the intricate interplay between molecular mechanisms, the tumor microenvironment, and therapy resistance. Cancer progression is driven not only by genetic and epigenetic alterations within tumor cells but also by dynamic interactions with surrounding stromal, immune, and vascular components. Understanding these complex networks is essential for identifying innovative therapeutic targets, especially for tumors with bad prognosis and for patients with low percentage of survival. This Topic welcomes contributions exploring emerging drugs, targeted therapies, and combination strategies designed to overcome resistance mechanisms and improve treatment efficacy. Particular attention is given to studies elucidating signaling pathways, tumor heterogeneity, immune modulation, and microenvironmental factors that influence therapeutic outcomes. By integrating basic, translational, and clinical research, this Topic aims to provide a comprehensive overview of cutting-edge approaches in anticancer drug development and to inspire new strategies for more effective and personalized cancer treatments.

Dr. Marzia Bruna Gariboldi
Dr. Elisa Martella
Topic Editors