Bone-Related Diseases: From Molecular Mechanisms to Therapy Development

Dear Colleagues,

The prevalence and incidence of bone-related diseases (fractures, osteoarthritis, osteoporosis, bone tumors, etc.) are increasing with the development of society, especially in the aging population. These diseases often result in pain and disability and incapacitate people in their daily life, which imposes a considerable socioeconomic burden worldwide. Therefore, it is imperative to explore the biomarkers and molecular mechanisms for early diagnosis and targeted treatment of bone-related diseases. With the rise in systematic biology and bioinformatics, more analytical techniques, including single-cell sequencing (scSeq), cytometry by time of flight (CyTOF), bulk RNA-Seq, etc., have been applied to achieve a deeper understanding of the mechanisms, such as genomics, proteomics, metabolomics, transcriptomics, etc. Particularly, molecular mechanisms of bone-related diseases could be identified from the analysis of genes, proteins, metabolites, etc. In this Topic, we welcome original research or review articles related to new insights into pathogenesis, potential biomarkers, and recent advances in the study of bone-related diseases.

Submission of original articles, reviews, mini reviews, and commentaries is welcomed.Topics of interest include but are not limited to:

• Mechanism of action study, including molecular and cellular mechanisms, key signaling pathways in bone-related diseases.
• Novel therapeutic strategies in the treatment of bone-related diseases.
• Biomarker studies in bone tumors and other bone-related diseases.
• Drug development, including PD, PK, toxicity, and efficacy evaluation for osteoarthritis, osteoporosis and other bone-related diseases.
• Clinical trials including osteoarthritis, osteoporosis, and bone tumors.

Dr. Xiao Wang
Dr. Xin Dong
Topic Editors