Topic Editors

Dr. Gérard Baldacchino
CEA Paris-Saclay, CNRS and Université Paris-Saclay, Gif-sur-Yvette, France
Prof. Dr. Eric Deutsch
Radiation Oncology Department, Gustave Roussy Cancer Campus, 94805 Villejuif, France
Dr. Marie Dutreix
1. Institut Curie, PSL Research University, CNRS, INSERM, UMR 3347, 91405 Orsay, France
2. Université Paris-Saclay, CNRS, UMR 3347, 91405 Orsay, France
Prof. Dr. Sandrine Lacombe
Institut des Sciences Moléculaires d'Orsay, Universite Paris-Saclay, Saint-Aubin, France
Dr. Erika Porcel
Institut des Sciences Moléculaires d’Orsay, Université Paris Saclay, CNRS UMR 8214, 91405 Orsay, France
Dr. Charlotte Robert
Molecular Predictors and New Targets in Oncology, Paris-Saclay University, Gustave Roussy, Villejuif, France
Dr. Emmanuelle Bourneuf
LCE, François Jacob Institute, CEA, Université Paris-Saclay, 92260 Fontenay-aux-Roses, France
Dr. João Santos Sousa
Laboratoire de Physique des Gaz et des Plasmas, CNRS, Université Paris-Saclay, Orsay, France
Dr. Aurélien de la Lande
Institut de Chimie Physique, CNRS, Université Paris Saclay, Paris, France

Innovative Radiation Therapies

Abstract submission deadline
31 December 2023
Manuscript submission deadline
30 June 2024
Viewed by
1621

Topic Information

Dear Colleagues,

With 9.6 million deaths in 2018, cancer is the second leading cause of death in the world (World Cancer Report, 2020). Each year, about 50% of all the people who have developed cancer are given radiation therapy at some point or another of their treatment. This non-invasive tool has become essential to treat tumors. Unfortunately, the conventional techniques currently used in clinic induce major side effects due to damage in healthy tissues. In addition, some tumors respond poorly to conventional treatments, in particular because of their radioresistance. Therefore, there is an urgent need for disruptions in technologies and protocols in the clinic to develop a precision medicine approach and personalized patient care.

This Topic is an initiative of the ambitious iNanoTheRad project of Université Paris-Saclay, which promotes innovative strategies based on irradiation by new sources (high-dose rates, high LET, spatially structured beams, plasmas) and the addition of tumor targeted nano-agents and drugs to improve the effects of radiotherapy. Strategies for treatment personalization based on artificial intelligence are also considered. This Topic is interdisciplinary and open to international experts and researchers in medical physics, radiation chemistry and physics, in numerical simulations and artificial intelligence, the development of radiation sources, radiobiology, nanoscience, nanomedicine, plasma medicine, radiotherapy, and oncology. It is intended to give visibility to important results and ideas concerning the formulation of the next generation of secured and personalized radiotherapy treatments from the lab bench to clinical applications.

Dr. Gérard Baldacchino
Prof. Dr. Eric Deutsch
Dr. Marie Dutreix
Prof. Dr. Sandrine Lacombe
Dr. Erika Porcel
Dr. Charlotte Robert
Dr. Emmanuelle Bourneuf
Dr. João Santos Sousa
Dr. Aurélien de la Lande
Topic Editors

Keywords

  • cancer
  • radiotherapy innovation
  • new radiation sources
  • new radiotherapy strategies
  • radiosensitizing nanoparticles
  • advanced strategies for radiotherapy
  • external radiotherapy in clinic
  • AI and imaging for radiation therapies
  • new sources and associated dosimetry for radiotherapy
  • new radiation therapies modalities
  • nanoparticle-enhanced radiotherapies in diagnosis and treatment
  • first principles simulations

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Cancers
cancers
6.575 5.8 2009 17.4 Days 2600 CHF Submit
Cells
cells
7.666 6.7 2012 16.4 Days 2400 CHF Submit
Journal of Clinical Medicine
jcm
4.964 4.4 2012 18 Days 2600 CHF Submit
Radiation
radiation
- - 2021 18.5 Days 1000 CHF Submit
Pharmaceutics
pharmaceutics
6.525 6.0 2009 15.9 Days 2600 CHF Submit
Applied Sciences
applsci
2.838 3.7 2011 14.9 Days 2300 CHF Submit
Nanomaterials
nanomaterials
5.719 6.6 2011 12.7 Days 2600 CHF Submit
Current Oncology
curroncol
3.109 3.5 1994 19.6 Days 1800 CHF Submit

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Published Papers (2 papers)

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Article
Orthovoltage X-ray Minibeam Radiation Therapy for the Treatment of Ocular Tumours—An In Silico Evaluation
Cancers 2023, 15(3), 679; https://doi.org/10.3390/cancers15030679 - 21 Jan 2023
Viewed by 534
Abstract
(1) Background: Radiotherapeutic treatments of ocular tumors are often challenging because of nearby radiosensitive structures and the high doses required to treat radioresistant cancers such as uveal melanomas. Although increased local control rates can be obtained with advanced techniques such as proton therapy [...] Read more.
(1) Background: Radiotherapeutic treatments of ocular tumors are often challenging because of nearby radiosensitive structures and the high doses required to treat radioresistant cancers such as uveal melanomas. Although increased local control rates can be obtained with advanced techniques such as proton therapy and stereotactic radiosurgery, these modalities are not always accessible to patients (due to high costs or low availability) and side effects in structures such as the lens, eyelids or anterior chamber remain an issue. Minibeam radiation therapy (MBRT) could represent a promising alternative in this regard. MBRT is an innovative new treatment approach where the irradiation field is composed of multiple sub-millimetric beamlets, spaced apart by a few millimetres. This creates a so-called spatial fractionation of the dose which, in small animal experiments, has been shown to increase normal tissue sparing while simultaneously providing high tumour control rates. Moreover, MBRT with orthovoltage X-rays could be easily implemented in widely available and comparably inexpensive irradiation platforms. (2) Methods: Monte Carlo simulations were performed using the TOPAS toolkit to evaluate orthovoltage X-ray MBRT as a potential alternative for treating ocular tumours. Dose distributions were simulated in CT images of a human head, considering six different irradiation configurations. (3) Results: The mean, peak and valley doses were assessed in a generic target region and in different organs at risk. The obtained doses were comparable to those reported in previous X-ray MBRT animal studies where good normal tissue sparing and tumour control (rat glioma models) were found. (4) Conclusions: A proof-of-concept study for the application of orthovoltage X-ray MBRT to ocular tumours was performed. The simulation results encourage the realisation of dedicated animal studies considering minibeam irradiations of the eye to specifically assess ocular and orbital toxicities as well as tumour response. If proven successful, orthovoltage X-ray minibeams could become a cost-effective treatment alternative, in particular for developing countries. Full article
(This article belongs to the Topic Innovative Radiation Therapies)
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Article
Effects of Microbeam Irradiation on Rodent Esophageal Smooth Muscle Contraction
Cells 2023, 12(1), 176; https://doi.org/10.3390/cells12010176 - 31 Dec 2022
Viewed by 630
Abstract
Background: High-dose-rate radiotherapy has shown promising results with respect to normal tissue preservation. We developed an ex vivo model to study the physiological effects of experimental radiotherapy in the rodent esophageal smooth muscle. Methods: We assessed the physiological parameters of the esophageal function [...] Read more.
Background: High-dose-rate radiotherapy has shown promising results with respect to normal tissue preservation. We developed an ex vivo model to study the physiological effects of experimental radiotherapy in the rodent esophageal smooth muscle. Methods: We assessed the physiological parameters of the esophageal function in ex vivo preparations of the proximal, middle, and distal segments in the organ bath. High-dose-rate synchrotron irradiation was conducted using both the microbeam irradiation (MBI) technique with peak doses greater than 200 Gy and broadbeam irradiation (BBI) with doses ranging between 3.5–4 Gy. Results: Neither MBI nor BBI affected the function of the contractile apparatus. While peak latency and maximal force change were not affected in the BBI group, and no changes were seen in the proximal esophagus segments after MBI, a significant increase in peak latency and a decrease in maximal force change was observed in the middle and distal esophageal segments. Conclusion: No severe changes in physiological parameters of esophageal contraction were determined after high-dose-rate radiotherapy in our model, but our results indicate a delayed esophageal function. From the clinical perspective, the observed increase in peak latency and decreased maximal force change may indicate delayed esophageal transit. Full article
(This article belongs to the Topic Innovative Radiation Therapies)
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