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Veterinary Sciences
Special Issues
Emerging Insights into Animal Pathogens and Mucosal Immunology
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Emerging Insights into Animal Pathogens and Mucosal Immunology

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Anatomy, Histology and Pathology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 596

Special Issue Editors

Prof. Dr. Tao Qin

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Guest Editor
College of Veterinary Medicine, Yangzhou University, Yangzhou 225012, China
Interests: zoonotic pathogens; epidemiology; veterinary immunology; mucosal immunity
Special Issues, Collections and Topics in MDPI journals
Dr. Jian Lin

E-Mail Website
Guest Editor
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
Interests: mucosal immunology; avian RNA virus; dendritic cells; RNA interference
Special Issues, Collections and Topics in MDPI journals
Dr. Lu Xia

E-Mail Website
Guest Editor
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China
Interests: pig diseases; enteric pathogens; host-pathogen interactions; mucosal immunity

Special Issue Information

Dear Colleagues,

This Special Issue aims to focus on advancing our understanding of animal pathogens and their implications for veterinary and wildlife health. We aim to cover a wide spectrum of topics, including pathogen biology, host–pathogen interactions, mechanisms of mucosal immunity, and the development of diagnostic, preventive, and therapeutic strategies. By integrating research into infectious agents affecting livestock, companion animals, and wildlife, this Special Issue seeks to provide new perspectives on combating infectious diseases, promoting animal health, and improving biosecurity measures. Contributions addressing multidisciplinary approaches or emerging technologies are particularly encouraged.

Prof. Dr. Tao Qin
Dr. Jian Lin
Dr. Lu Xia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • animal pathogens
  • host–pathogen interactions
  • mucosal immunity
  • infectious diseases
  • veterinary science
  • zoonotic diseases
  • diagnostic tools
  • pathogen biology
  • vaccine development
  • biosecurity

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

24 pages, 4187 KiB  
Article
Biofilm Formation, Antibiotic Resistance, and Virulence Analysis of Human and Avian Origin Klebsiella pneumoniae from Jiangsu, China
by Yulu Xue, Fangyu Shi, Bangyue Zhou, Yi Shi, Wenqing Luo, Jing Zhu, Yang Yang, Sujuan Chen, Tao Qin, Daxin Peng and Yinyan Yin
Vet. Sci. 2025, 12(7), 628; https://doi.org/10.3390/vetsci12070628 - 30 Jun 2025
Viewed by 361
Abstract
Klebsiella pneumoniae, a zoonotic pathogen of global concern, poses significant threats to both veterinary and public health. Here, a comparative study characterized 14 clinical isolates (7 avian-derived, 7 human-derived) from Jiangsu, China, through integrated genomic and phenotypic analyses. Firstly, multilocus sequence typing [...] Read more.
Klebsiella pneumoniae, a zoonotic pathogen of global concern, poses significant threats to both veterinary and public health. Here, a comparative study characterized 14 clinical isolates (7 avian-derived, 7 human-derived) from Jiangsu, China, through integrated genomic and phenotypic analyses. Firstly, multilocus sequence typing (MLST) revealed distinct epidemiological patterns: the same ST type in avian isolates was circulating between different species and different regions, whereas it was not found in human isolates. In addition, hypervirulent Klebsiella pneumoniae (hvKP) phenotypes confirmed by string test were exclusive to two human isolates (KP15, KP20). Secondly, biofilm detection demonstrated 78.6% (11/14) of isolates possessed biofilm-forming capacity, with cellulose but not curli as the predominant matrix component. Human-derived KP15 and KP20 had the strongest biofilm formation ability in all isolates. Antimicrobial susceptibility profiling identified serious multidrug resistance in both avian and human isolates. Virulence gene analysis revealed striking disparities, with human isolates harboring 10–20 virulence factors (median 15) versus 6–7 (median 6.5) in avian counterparts. Finally, functional pathogenesis assessments demonstrated human-derived strains exhibited stronger epithelial cell adhesion (2-fold higher) and invasion (1.97-fold higher) in Calu-3 cell models and paradoxically showed reduced macrophage phagocytosis (2.85-fold lower at 2 h) for immune escape. In vivo models confirmed dose-dependent mortality, with human isolates demonstrating higher lethality in both Galleria mellonella and mice. Virulence gene burden positively correlated with mortality outcomes. These findings delineate critical host adaptation differences in Klebsiella pneumoniae populations and provide empirical evidence for pathogen transmission dynamics at the human-animal interface. Full article
(This article belongs to the Special Issue Emerging Insights into Animal Pathogens and Mucosal Immunology)
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