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Biomedicines
Special Issues
Diseases and Regeneration for Muscle, Joint and Bone
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Diseases and Regeneration for Muscle, Joint and Bone

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 2409

Special Issue Editors

Dr. Chung-Hwan Chen

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Guest Editor
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan
Interests: osteoporosis; bone and cartilage; EGCG catechin; osteoarthritis; stem cell; development/degeneration of spine
Special Issues, Collections and Topics in MDPI journals
Dr. Sung-Yen Lin

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Guest Editor
Department of Orthopaedic Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Interests: osteoporosis; bone and cartilage; EGCG catechin; osteoarthritis
Dr. Cheng-Jung Ho

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Guest Editor
Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Interests: osteoporosis; bone and cartilage; EGCG catechin; osteoarthritis

Special Issue Information

Dear Colleagues,

As the population continues to age, more and more people will suffer from disease in musculoskeletal systems including bones, joints, and muscles. Therefore, basic and clinical research on the epidemiology, pathogenesis, prevention, and treatment of bone, joint, and muscle diseases is of value. In this Special Issue, research related musculoskeletal diseases and regeneration is welcomed.

Dr. Chung-Hwan Chen
Dr. Sung-Yen Lin
Dr. Cheng-Jung Ho
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • arthritis
  • bone
  • epidemiology
  • joint
  • muscle
  • osteoporosis
  • pathogenesis
  • sarcopenia
  • treatment

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Published Papers (2 papers)

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Research

11 pages, 1078 KiB  
Article
Between Consecutive Fractures: Time and Sex as Dominant Factors in Type and Severity Concordance of Contralateral Hip Injuries
by Neta Leshem, Ido Stahl, Farouk Khury and Ianiv Trior Simonovich
Biomedicines 2025, 13(1), 114; https://doi.org/10.3390/biomedicines13010114 - 6 Jan 2025
Viewed by 1073
Abstract
Background/Objectives: Hip fractures present a global public health concern, with a forecasted rise in incidence and having associated increased mortality rates. This study aimed to investigate whether the AO Foundation/Orthopaedic Trauma Association (AO/OTA) classification of a first hip fracture can predict the [...] Read more.
Background/Objectives: Hip fractures present a global public health concern, with a forecasted rise in incidence and having associated increased mortality rates. This study aimed to investigate whether the AO Foundation/Orthopaedic Trauma Association (AO/OTA) classification of a first hip fracture can predict the location and severity of a subsequent contralateral fracture. Methods: We retrospectively evaluated patients with non-simultaneous bilateral hip fractures between January 2000 and February 2021 and analyzed the type and severity of each fracture using the AO/OTA classification system, interval between fractures (TI), and patients’ characteristics, including sex, age at time of each fracture, and radiographic measurements of hip morphology. Results: The study included 182 fractures in 91 patients (68% women, mean age: 79.5 and 82.2 years at first and second fractures, respectively; mean TI: 975 days). A strong association (lambda = 0.437, p < 0.001) was demonstrated between the first and second fracture classifications, which was higher in men (lambda = 0.60, p < 0.001) and for TI < 3 years (lambda = 0.625–0.688, p < 0.001). The mean TI was significantly shorter between the first and subsequent identical fractures than between different fracture types. However, mean hip morphological features did not significantly differ between groups. Conclusions: The initial hip fracture classification significantly predicted the type and severity of a subsequent contralateral fracture, particularly within 3 years and in men. Providing appropriate patient guidance and preventive measures is crucial, particularly for those with primary fractures that are associated with higher morbidity and mortality. Specific fracture-focused interventions, such as preventive intramedullary nail fixation, should be considered. Full article
(This article belongs to the Special Issue Diseases and Regeneration for Muscle, Joint and Bone)
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18 pages, 9960 KiB  
Article
Comparative Analysis of Extracorporeal Shockwave Therapy, Bisphosphonate, and Wharton Jelly-Derived Mesenchymal Stem Cells in Preserving Bone and Cartilage Integrity and Modulating IL31, IL33, and BMP2 in the Cartilage of Ovariectomized Rat Model
by Jai-Hong Cheng, Cheng-Wei Chen, Wen-Yi Chou, Po-Cheng Chen, Kuan-Ting Wu, Shun-Wun Jhan, Shan-Ling Hsu, Yi-No Wu and Hou-Tsung Chen
Biomedicines 2024, 12(12), 2823; https://doi.org/10.3390/biomedicines12122823 - 12 Dec 2024
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Abstract
Background: Osteoporosis (OP) is a chronic inflammatory bone disease characterized by reduced bone structure and strength, leading to increased fracture risk. Effective therapies targeting both bone and cartilage are limited. This study compared the therapeutic effects of extracorporeal shockwave therapy (ESWT), bisphosphonate (Aclasta), [...] Read more.
Background: Osteoporosis (OP) is a chronic inflammatory bone disease characterized by reduced bone structure and strength, leading to increased fracture risk. Effective therapies targeting both bone and cartilage are limited. This study compared the therapeutic effects of extracorporeal shockwave therapy (ESWT), bisphosphonate (Aclasta), and human Wharton jelly-derived mesenchymal stem cells (WJMSCs) in a rat model of OP. Methods: Female rats were assigned to four groups: Sham (no surgery or treatment), OP (bilateral ovariectomy, OVX), ESWT (OVX + ESWT on both tibias at 0.25 mJ/mm2, 1500 impulses per tibia), Aclasta (OVX + zoledronic acid 0.1 mg/kg via tail vein injection), and WJMSC (OVX + 2 × 10⁶ WJMSCs). Pathological changes, bone microarchitecture (by micro-CT), serum cytokines (by ELISA), and tissue-specific molecular markers (by immunohistochemistry) were evaluated. Results: All treatments improved bone density, preserved cartilage, and modulated cytokines (IL31, IL33, VEGF, and BMP2), with Aclasta showing the greatest improvements in bone parameters and cartilage preservation. ESWT and WJMSC also demonstrated significant effects, with ESWT highlighting non-invasive chondroprotective potential. Conclusions: Aclasta provided the best overall therapeutic response, particularly in bone regeneration. However, ESWT and WJMSC also showed comparable chondroprotective effects. ESWT emerges as a promising non-invasive alternative for OP management when pharmacological or cell-based therapies are not feasible. Full article
(This article belongs to the Special Issue Diseases and Regeneration for Muscle, Joint and Bone)
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