The Role of the Bone Marrow Microenvironment in Normal Hematopoiesis and Leukemia Development
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 334
Special Issue Editors
Interests: bone marrow microenvironment; hematopoietic stem cells; acute myeloid leukemia
Special Issue Information
Dear Colleagues,
The bone marrow microenvironment (BMM) is considered the main sanctuary of hematopoietic stem and progenitor cells (HSPCs). The BMM is composed of many different cell types, including stromal cells, endothelial cells, and neuronal cells, and regulates the generation of blood through direct contact or the secretion of different signaling molecules. Any alterations in the BMM due to aging, infection, or malignant transformation alter HSPC potential and consequently hematopoiesis. Due to their uncanny resemblance to HSPCs, leukemia cells reside in the same microenvironment. Not only do some physiological conditions, such as the aging of the BMM, favor leukemia development, but the leukemic cells in turn modulate the BMM in a way that supports their progression. Understanding the interplay between normal and malignant cells in the bone marrow microenvironment can hopefully provide insight into new therapeutic targets in different malignancies of the blood.
This Special Issue, entitled “The Role of the Bone Marrow Microenvironment in Normal Hematopoiesis and Leukemia Development”, aims to shed light on the role of this complex environment and how it works under normal and malignant conditions.
Dr. Mohammad Houshmand
Dr. Jelena Milosevic
Guest Editors
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Keywords
- bone marrow microenvironment
- hematopoietic stem cells
- hematopoiesis
- leukemia
- metabolism
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