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4 Results Found

  • Article
  • Open Access
31 Citations
6,756 Views
24 Pages

Functional Therapeutic Target Validation Using Pediatric Zebrafish Xenograft Models

  • Charlotte Gatzweiler,
  • Johannes Ridinger,
  • Sonja Herter,
  • Xenia F. Gerloff,
  • Dina ElHarouni,
  • Yannick Berker,
  • Roland Imle,
  • Lukas Schmitt,
  • Sina Kreth and
  • Ina Oehme
  • + 17 authors

8 February 2022

The survival rate among children with relapsed tumors remains poor, due to tumor heterogeneity, lack of directly actionable tumor drivers and multidrug resistance. Novel personalized medicine approaches tailored to each tumor are urgently needed to i...

(This article belongs to the Special Issue Application of Emerging Technologies in Zebrafish and Mammalian Cancer Models for Disease Characterization and Therapeutic Target Discovery)
  • Article
  • Open Access
23 Citations
4,554 Views
15 Pages

Zebrafish Patient-Derived Xenograft Model to Predict Treatment Outcomes of Colorectal Cancer Patients

  • Gregorio Di Franco,
  • Alice Usai,
  • Margherita Piccardi,
  • Perla Cateni,
  • Matteo Palmeri,
  • Luca Emanuele Pollina,
  • Raffaele Gaeta,
  • Federica Marmorino,
  • Chiara Cremolini and
  • Luca Morelli
  • + 3 authors

The use of zebrafish embryos for personalized medicine has become increasingly popular. We present a co-clinical trial aiming to evaluate the use of zPDX (zebrafish Patient-Derived Xenografts) in predicting the response to chemotherapy regimens used...

(This article belongs to the Section Cancer Biology and Oncology)
  • Review
  • Open Access
28 Citations
6,260 Views
24 Pages

Zebrafish Cancer Avatars: A Translational Platform for Analyzing Tumor Heterogeneity and Predicting Patient Outcomes

  • Majd A. Al-Hamaly,
  • Logan T. Turner,
  • Angelica Rivera-Martinez,
  • Analiz Rodriguez and
  • Jessica S. Blackburn

24 January 2023

The increasing number of available anti-cancer drugs presents a challenge for oncologists, who must choose the most effective treatment for the patient. Precision cancer medicine relies on matching a drug with a tumor’s molecular profile to opt...

(This article belongs to the Special Issue Zebrafish as a Model in Human Disease)
  • Article
  • Open Access
18 Citations
4,038 Views
15 Pages

Zebrafish Patient-Derived Xenografts Identify Chemo-Response in Pancreatic Ductal Adenocarcinoma Patients

  • Alice Usai,
  • Gregorio Di Franco,
  • Margherita Piccardi,
  • Perla Cateni,
  • Luca Emanuele Pollina,
  • Caterina Vivaldi,
  • Enrico Vasile,
  • Niccola Funel,
  • Matteo Palmeri and
  • Luca Morelli
  • + 5 authors

17 August 2021

It is increasingly evident the necessity of new predictive tools for the treatment of pancreatic ductal adenocarcinoma in a personalized manner. We present a co-clinical trial testing the predictiveness of zPDX (zebrafish patient-derived xenograft) f...

(This article belongs to the Special Issue Recent Advances in Pancreatic Ductal Adenocarcinoma)