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18 Results Found

  • Article
  • Open Access
35 Citations
6,086 Views
11 Pages

Cardiac and Peripheral Autonomic Responses to Orthostatic Stress During Transcutaneous Vagus Nerve Stimulation in Healthy Subjects

  • Eleonora Tobaldini,
  • Edgar Toschi-Dias,
  • Liliane Appratto de Souza,
  • Karina Rabello Casali,
  • Marco Vicenzi,
  • Giulia Sandrone,
  • Chiara Cogliati,
  • Maria Teresa La Rovere,
  • Gian Domenico Pinna and
  • Nicola Montano

11 April 2019

Previous studies showed that transcutaneous vagus nerve stimulation (tVNS) modulates the autonomic nervous system (ANS) in resting condition. However, the autonomic regulation in response to an orthostatic challenge during tVNS in healthy subjects re...

  • Review
  • Open Access
506 Views
16 Pages

12 January 2026

For decades, researchers have explored the therapeutic potential of the vagus nerve through vagus nerve stimulation (VNS). Initially developed for epilepsy, VNS has since been applied to treat resistant depression, stroke recovery, and inflammatory c...

  • Article
  • Open Access
31 Citations
8,635 Views
15 Pages

Effects of Stimulus Frequency, Intensity, and Sex on the Autonomic Response to Transcutaneous Vagus Nerve Stimulation

  • Hirotake Yokota,
  • Mutsuaki Edama,
  • Ryo Hirabayashi,
  • Chie Sekine,
  • Naofumi Otsuru,
  • Kei Saito,
  • Sho Kojima,
  • Shota Miyaguchi and
  • Hideaki Onishi

4 August 2022

This study aimed to determine how transcutaneous vagus nerve stimulation (tVNS) alters autonomic nervous activity by comparing the effects of different tVNS frequencies and current intensities. We also investigated the sex-dependent autonomic respons...

  • Article
  • Open Access
14 Citations
4,055 Views
9 Pages

The Effect of Transcutaneous Vagus Nerve Stimulation in Patients with Polymyalgia Rheumatica

  • Jacob Venborg,
  • Anne-Marie Wegeberg,
  • Salome Kristensen,
  • Birgitte Brock,
  • Christina Brock and
  • Mogens Pfeiffer-Jensen

16 November 2021

(1) Polymyalgia rheumatica (PMR) is an inflammatory disease characterised by pain, morning stiffness, and reduced quality of life. Recently, vagus nerve stimulation (VNS) was shown to have anti-inflammatory effects. We aimed to examine the effect of...

  • Article
  • Open Access
40 Citations
6,671 Views
12 Pages

Transcutaneous Vagus Nerve Stimulation Modulates EEG Microstates and Delta Activity in Healthy Subjects

  • Lorenzo Ricci,
  • Pierpaolo Croce,
  • Jacopo Lanzone,
  • Marilisa Boscarino,
  • Filippo Zappasodi,
  • Mario Tombini,
  • Vincenzo Di Lazzaro and
  • Giovanni Assenza

25 September 2020

Transcutaneous vagus nerve stimulation (tVNS) is an alternative non-invasive method for the electrical stimulation of the vagus nerve with the goal of treating several neuropsychiatric disorders. The objective of this study is to assess the effects o...

  • Perspective
  • Open Access
3 Citations
6,253 Views
10 Pages

26 November 2024

A new therapeutic approach, known as neuromodulation therapy—which encompasses a variety of interventional techniques meant to alter the nervous system in order to achieve therapeutic effects—has emerged in recent years as a result of adv...

  • Article
  • Open Access
1 Citations
2,366 Views
17 Pages

Low-Frequency Electrical Stimulation of the Auricular Branch of the Vagus Nerve in Patients with ST-Elevation Myocardial Infarction: A Randomized Clinical Trial

  • Sofia Kruchinova,
  • Milana Gendugova,
  • Alim Namitokov,
  • Maria Sokolskaya,
  • Irina Gilevich,
  • Zoya Tatarintseva,
  • Maria Karibova,
  • Vasiliy Danilov,
  • Nikita Simakin and
  • Vladimir Shvartz
  • + 2 authors

10 March 2025

Background: Despite the vast evidence of the beneficial effect of vagus nerve stimulation on the course of myocardial infarction confirmed in studies using animal models, the introduction of this method into actual clinical practice remains uncommon....

  • Article
  • Open Access
2 Citations
10,248 Views
12 Pages

30 December 2024

Background: The role of autonomic nervous system (ANS) modulation in chronic neck pain remains elusive. Transcutaneous vagus nerve stimulation (t-VNS) provides a novel, non-invasive means of potentially mitigating chronic neck pain. This study aimed...

  • Article
  • Open Access
11 Citations
9,738 Views
13 Pages

Transcutaneous Vagus Nerve Stimulation for Insomnia in People Living in Places or Cities with High Altitudes: A Randomized Controlled Trial

  • Liang Zhang,
  • Yinchuan Jin,
  • Qintao Zhang,
  • Hongyao Liu,
  • Chen Chen,
  • Lei Song,
  • Xiao Li,
  • Zhujing Ma and
  • Qun Yang

Background: The purpose of this study was to investigate the effectiveness and safety of transcutaneous vagus nerve stimulation (tVNS) to improve insomnia in the special environment of a plateau. Methods: This study was a single-center, single-blind,...

  • Article
  • Open Access
36 Citations
10,003 Views
10 Pages

26 September 2022

(1) Background: The purpose of this study was to investigate the efficacy and safety of transcutaneous vagus nerve stimulation (t-VNS) in the treatment of primary insomnia. (2) Methods: This is a single center, randomized, double-blind study. A total...

  • Study Protocol
  • Open Access
18 Citations
12,867 Views
12 Pages

Non-Invasive Transcutaneous Vagus Nerve Stimulation for the Treatment of Fibromyalgia Symptoms: A Study Protocol

  • Andrés Molero-Chamizo,
  • Michael A. Nitsche,
  • Armin Bolz,
  • Rafael Tomás Andújar Barroso,
  • José R. Alameda Bailén,
  • Jesús Carlos García Palomeque and
  • Guadalupe Nathzidy Rivera-Urbina

12 January 2022

Stimulation of the vagus nerve, a parasympathetic nerve that controls the neuro-digestive, vascular, and immune systems, induces pain relief, particularly in clinical conditions such as headache and rheumatoid arthritis. Transmission through vagal af...

  • Article
  • Open Access
3 Citations
3,351 Views
20 Pages

Vagal Stimulation Ameliorates Non-Alcoholic Fatty Liver Disease in Rats

  • Hany A. Elkattawy,
  • Samar Mortada Mahmoud,
  • Ahmed El-Sayed Hassan,
  • Ahmed Behiry,
  • Hasnaa Ali Ebrahim,
  • Ateya Megahed Ibrahim,
  • Donia Elsaid Fathi Zaghamir,
  • Mohamed El-Sherbiny and
  • Sherein F. El-Sayed

Background: The harmful consequences of non-alcoholic fatty liver disease (NAFLD) are posing an increasing threat to public health as the incidence of diabetes and obesity increases globally. A non-invasive treatment with a range of autonomic and met...

  • Article
  • Open Access
28 Citations
7,593 Views
15 Pages

27 September 2022

Vascular cognitive impairment (VCI) is a common sequela of cerebrovascular disorders. Although transcutaneous auricular vagus nerve stimulation (taVNS) has been considered a complementary treatment for various cognitive disorders, preclinical data on...

  • Review
  • Open Access
7 Citations
7,965 Views
26 Pages

27 December 2024

Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by a range of motor and non-motor symptoms (NMSs) that significantly impact patients’ quality of life. This review aims to synthesize the current literatur...

  • Article
  • Open Access
31 Citations
6,424 Views
9 Pages

Effect of Transcutaneous Vagus Nerve Stimulation in Erosive Hand Osteoarthritis: Results from a Pilot Trial

  • Alice Courties,
  • Camille Deprouw,
  • Emmanuel Maheu,
  • Eric Gibert,
  • Jacques-Eric Gottenberg,
  • Julien Champey,
  • Béatrice Banneville,
  • Camille Chesnel,
  • Gérard Amarenco and
  • Jérémie Sellam
  • + 2 authors

18 February 2022

Beyond its effect on vegetative functions, the activation of the vagus nerve inhibits inflammation and reduces pain signaling. The aim of this open-label pilot study was to determine the efficacy and tolerance of transcutaneous auricular VNS (taVNS)...

  • Review
  • Open Access
10 Citations
4,363 Views
15 Pages

31 January 2024

Takotsubo syndrome (TTS) is a cardiomyopathy that clinically presents as a transient and reversible left ventricular wall motion abnormality (LVWMA). Recovery can occur spontaneously within hours or weeks. Studies have shown that it mainly affects ol...

  • Systematic Review
  • Open Access
445 Views
18 Pages

Introduction: Stroke is a leading cause of adult-onset disability. Non-invasive brain stimulation (NIBS) techniques such as repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), and transcutaneous vagus...

  • Review
  • Open Access
4 Citations
5,130 Views
25 Pages

29 March 2025

Patients with type 2 diabetes mellitus (T2DM) predominantly experience mortality due to cardiovascular diseases (CVD), particularly in low- and middle-income nations. Among these, heart failure (HF) is the most severe cardiovascular complication in t...