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Article

2 Citations

3,099 Views

14 Pages

Highly Regioselective 1,3-Dipolar Cycloaddition of Nitrilimines and Thioaurones Towards Spiro-2-Pyrazolines: Synthesis, Characterization, and Mechanistic Study

Mohamed Bakhouch,
Bouchra Es-Sounni,
Ayoub Ouaddi,
Khaoula Oudghiri,
Mohammed Chalkha,
Lahoucine Bahsis,
Taoufiq Benali,
Mohamed Bourass,
Rabiaa Fdil and
Mohamed El Yazidi
+ 1 author

Reactions2024, 5(4), 1066-1079;https://doi.org/10.3390/reactions5040056

14 December 2024

In this paper, we report a highly regioselective 1,3-dipolar cycloaddition (1,3-DC) reaction of nitrilimines with thioaurone derivatives that afforded the hitherto unreported spiropyrazolines. Spectroscopic and spectrometric data were utilized to con...

(This article belongs to the Special Issue Cycloaddition Reactions at the Beginning of the Third Millennium)

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Review

8 Citations

4,720 Views

23 Pages

Scaffold-Hopping Strategies in Aurone Optimization: A Comprehensive Review of Synthetic Procedures and Biological Activities of Nitrogen and Sulfur Analogues

Gabriele La Monica,
Federica Alamia,
Alessia Bono,
Antonino Lauria and
Annamaria Martorana

Molecules2024, 29(12), 2813;https://doi.org/10.3390/molecules29122813

13 June 2024

Aurones, particular polyphenolic compounds belonging to the class of minor flavonoids and overlooked for a long time, have gained significative attention in medicinal chemistry in recent years. Indeed, considering their unique and outstanding biologi...

(This article belongs to the Special Issue Heterocyclic Bioactive Small Molecules: Advances in Structure Analysis and Drug Discovery in Heterocyclic Chemistry)

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