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  • Article
  • Open Access
4 Citations
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Genome-Wide Association Study Suggests the Variant rs7551288*A within the DHCR24 Gene Is Associated with Poor Overall Survival in Melanoma Patients

  • Annette Pflugfelder,
  • Xuan Ling Hilary Yong,
  • Kasturee Jagirdar,
  • Thomas K. Eigentler and ,
  • H. Peter Soyer,
  • Richard A. Sturm,
  • Lukas Flatz and
  • David L. Duffy
  • + 3 authors+ 0 author
Cancers2022, 14(10), 2410;https://doi.org/10.3390/cancers14102410

13 May 2022

Melanoma incidence rates are high among individuals with fair skin and multiple naevi. Established prognostic factors are tumour specific, and less is known about prognostic host factors. A total of 556 stage I to stage IV melanoma patients from Germ...

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  • Article
  • Open Access
9 Citations
5,518 Views
12 Pages
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DHCR24, a Key Enzyme of Cholesterol Synthesis, Serves as a Marker Gene of the Mouse Adrenal Gland Inner Cortex

  • Huifei Sophia Zheng,
  • Yuan Kang,
  • Qiongxia Lyu,
  • Kristina Junghans and ,
  • Courtney Cleary,
  • Olivia Reid,
  • Greer Cauthen,
  • Karly Laprocina and
  • Chen-Che Jeff Huang
  • + 4 authors+ 0 author
Int. J. Mol. Sci.2023, 24(2), 933;https://doi.org/10.3390/ijms24020933

4 January 2023

Steroid hormones are synthesized through enzymatic reactions using cholesterol as the substrate. In steroidogenic cells, the required cholesterol for steroidogenesis can be obtained from blood circulation or synthesized de novo from acetate. One of t...

(This article belongs to the Special Issue Molecular Mechanisms of Steroid Hormone Biosynthesis and Action)
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