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8 Results Found

  • Article
  • Open Access
25 Citations
5,608 Views
17 Pages

Resveratrol Metabolites Are Able to Reduce Steatosis in Cultured Hepatocytes

  • Jenifer Trepiana,
  • Stéphanie Krisa,
  • Elodie Renouf and
  • María Puy Portillo

30 September 2020

Steatosis is characterized primarily by excessive lipid accumulation in the form of triglycerides in the liver. Although resveratrol shows a low bioavailability, it has significant positive effects on steatosis. The aim of this study was to analyze w...

  • Article
  • Open Access
2 Citations
1,805 Views
23 Pages

Resveratrol and Its Metabolite as Potential Allosteric Regulators of Monoamine Oxidase A Activity in the Brain and Liver Under Chronic Predator Stress

  • Jurica Novak,
  • Olga B. Tseilikman,
  • Vladislav A. Shatilov,
  • Maxim S. Zhukov,
  • Vadim A. Shevyrin,
  • Zuhra R. Khismatullina,
  • Albina M. Fedorova,
  • Georgiy N. Patrikyan,
  • Timur L. Khaibullin and
  • Vadim E. Tseilikman

Background: Resveratrol has been shown to modulate stress-related anxiety by reducing brain monoamine oxidase A (MAO-A) activity. However, the molecular mechanism underlying this neurochemical effect remains unknown. In this study, we employed in sil...

  • Article
  • Open Access
151 Citations
9,773 Views
17 Pages

Increased Oral Bioavailability of Resveratrol by Its Encapsulation in Casein Nanoparticles

  • Rebeca Peñalva,
  • Jorge Morales,
  • Carlos J. González-Navarro,
  • Eneko Larrañeta,
  • Gemma Quincoces,
  • Ivan Peñuelas and
  • Juan M. Irache

18 September 2018

Resveratrol is a naturally occurring polyphenol that provides several health benefits including cardioprotection and cancer prevention. However, its biological activity is limited by a poor bioavailability when taken orally. The aim of this work was...

  • Article
  • Open Access
48 Citations
7,424 Views
15 Pages

Involvement of UDP-Glucuronosyltransferases and Sulfotransferases in the Excretion and Tissue Distribution of Resveratrol in Mice

  • Michaela Böhmdorfer,
  • Akos Szakmary,
  • Robert H. Schiestl,
  • Javier Vaquero,
  • Juliane Riha,
  • Stefan Brenner,
  • Theresia Thalhammer,
  • Thomas Szekeres and
  • Walter Jäger

12 December 2017

Resveratrol is a naturally occurring polyphenolic compound with various pharmacological activities. It is unknown whether the expression of metabolizing enzymes correlates with resveratrol levels in organs and tissues. Therefore, we investigated the...

  • Communication
  • Open Access
71 Citations
10,109 Views
11 Pages

Piceatannol and Its Metabolite, Isorhapontigenin, Induce SIRT1 Expression in THP-1 Human Monocytic Cell Line

  • Shinpei Kawakami,
  • Yosuke Kinoshita,
  • Hiroko Maruki-Uchida,
  • Koji Yanae,
  • Masahiko Sai and
  • Tatsuhiko Ito

30 October 2014

Piceatannol is a phytochemical that is present in large amounts in passion fruit (Passiflora edulis) seeds, and is an analog of resveratrol. Recently, the absorption and metabolism of piceatannol were investigated in rats, and isorhapontigenin, O-met...

  • Article
  • Open Access
10 Citations
3,758 Views
10 Pages

Activity of Pterostilbene Metabolites against Liver Steatosis in Cultured Hepatocytes

  • Jenifer Trepiana,
  • Stéphanie Krisa and
  • María Puy Portillo

20 November 2020

Pterostilbene is a dimethyl ether derivative of resveratrol, less metabolized than its analogue, due to the substitution of two hydroxyl groups with methoxyl groups. Nevertheless, the amounts of pterostilbene phase II metabolites found in plasma and...

  • Article
  • Open Access
1,011 Views
26 Pages

Zeolite in Vineyard: Innovative Agriculture Management Against Drought Stress

  • Eleonora Cataldo,
  • Sergio Puccioni,
  • Aleš Eichmeier and
  • Giovan Battista Mattii

Discovering, analyzing, and finding a key to understanding the physiological and biochemical responses that Vitis vinifera L. undertakes against drought stress is of fundamental importance for this profitable crop. Today’s considerable climatic...

  • Review
  • Open Access
208 Citations
12,929 Views
33 Pages

Due to their biological activities, both in plants and in humans, there is a great interest in finding natural sources of phenolic compounds or ways to artificially manipulate their levels. During the last decade, a significant amount of these compou...