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Article

2 Citations

3,381 Views

11 Pages

Synthesis and PET Imaging Biodistribution Studies of Radiolabeled Iododiflunisal, a Transthyretin Tetramer Stabilizer, Candidate Drug for Alzheimer’s Disease

Sameer M. Joshi,
Thomas C. Wilson,
Zibo Li,
Sean Preshlock,
Vanessa Gómez-Vallejo,
Véronique Gouverneur,
Jordi Llop and
Gemma Arsequell

Molecules2024, 29(2), 488;https://doi.org/10.3390/molecules29020488

18 January 2024

The small-molecule iododiflunisal (IDIF) is a transthyretin (TTR) tetramer stabilizer and acts as a chaperone of the TTR-Amyloid beta interaction. Oral administration of IDIF improves Alzheimer’s Disease (AD)-like pathology in mice, although th...

(This article belongs to the Section Medicinal Chemistry)

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Article

25 Citations

5,983 Views

16 Pages

Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer

Ellen Y. Cotrina,
Ângela Oliveira,
José Pedro Leite,
Jordi Llop,
Luis Gales,
Jordi Quintana,
Isabel Cardoso and
Gemma Arsequell

Int. J. Mol. Sci.2020, 21(19), 7166;https://doi.org/10.3390/ijms21197166

28 September 2020

Transthyretin (TTR) is a homotetrameric protein involved in human amyloidosis, including familial amyloid polyneuropathy (FAP). Discovering small-molecule stabilizers of the TTR tetramer is a therapeutic strategy for these diseases. Tafamidis, the on...

(This article belongs to the Section Molecular Neurobiology)

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