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10 Results Found

  • Article
  • Open Access
22 Citations
5,470 Views
18 Pages

Metronidazole-Loaded Porous Matrices for Local Periodontitis Treatment: In Vitro Evaluation and In Vivo Pilot Study

  • Dorota Kida,
  • Bożena Karolewicz,
  • Adam Junka,
  • Aleksandra Sender-Janeczek,
  • Irena Duś,
  • Dominik Marciniak and
  • Małgorzata Szulc

25 October 2019

Periodontal therapy focuses on thorough removal of subgingival calculus and plaque products followed by the smoothing out of root surfaces. However, such conventional mechanotherapeutic approaches are inefficient with regard to microbial biofilm elim...

  • Article
  • Open Access
14 Citations
3,323 Views
18 Pages

Helicobacter pylori is thought to be the most common cause of peptic and duodenal ulcers. Eradication of this organism is now considered one of the lines of treatment of gastric and duodenal ulcers. This can be achieved via local delivery of antibact...

  • Article
  • Open Access
5 Citations
3,746 Views
19 Pages

Development and Optimization of a Novel Lozenge Containing a Metronidazole-Peppermint Oil-Tranexamic Acid Self-Nanoemulsified Delivery System to Be Used after Dental Extraction: In Vitro Evaluation and In Vivo Appraisal

  • Mohammed Alissa,
  • Ahmed Hjazi,
  • Ghadah S. Abusalim,
  • Ghfren S. Aloraini,
  • Suad A. Alghamdi,
  • Waleed Y. Rizg,
  • Khaled M. Hosny,
  • Jazia A. Alblowi and
  • Hanaa Alkharobi

In-depth studies on essential oil–based nanoemulsions (NEs) have centered on a variety of oral health issues. NEs improve the delivery of nonpolar active agents to sites and thereby boost the dissolution and distribution of the agents. Metronid...

  • Article
  • Open Access
53 Citations
6,357 Views
17 Pages

The purpose of this study was to prepare poly (D-L) lactide-co-glycolide (PLGA) and poly ε-caprolactone (PCL) nanofibers containing metronidazole and amoxicillin using an electrospinning process as intrapocket sustained-release drug delivery systems...

  • Article
  • Open Access
15 Citations
5,603 Views
20 Pages

4 September 2022

Fruits containing antioxidants, e.g., anthocyanins, exhibit antimicrobial activities. The emergence of drug resistance represents a major challenge in eradicating H. pylori. The current study aims to explore the effect of pomegranate exocarp anthocya...

  • Article
  • Open Access
4 Citations
1,966 Views
18 Pages

12 June 2024

Pelvic prolapse stands as a substantial medical concern, notably impacting a significant segment of the population, predominantly women. This condition, characterized by the descent of pelvic organs, such as the uterus, bladder, or rectum, from their...

  • Review
  • Open Access
6 Citations
2,342 Views
16 Pages

The Role of Autologous Platelet Concentrates as a Local Antibiotic Delivery System: A Systematic Scoping Review

  • Roberta Gasparro,
  • Federica Di Spirito,
  • Maria Domenica Campana,
  • Gilberto Sammartino and
  • Alessandro E. di Lauro

6 September 2024

Objectives: Ongoing research has begun to develop innovative approaches to deliver local antibiotics while minimizing systemic side effects, antimicrobial resistance, and limited tissue penetration. Autologous platelet concentrates (APCs) offer promi...

  • Article
  • Open Access
14 Citations
3,155 Views
13 Pages

Functionalized Ultrasmall Iron Oxide Nanoparticles for T1-Weighted Magnetic Resonance Imaging of Tumor Hypoxia

  • Lei Yang,
  • Mohammad Javad Afshari,
  • Jianxian Ge,
  • Dandan Kou,
  • Lei Chen,
  • Dandan Zhou,
  • Cang Li,
  • Shuwang Wu,
  • Leshuai Zhang and
  • Jianfeng Zeng
  • + 3 authors

15 October 2022

Hypoxia is a common biological condition in many malignant solid tumors that plays an imperative role in regulating tumor growth and impacting the treatment’s therapeutic effect. Therefore, the hypoxia assessment is of great significance in pre...

  • Article
  • Open Access
5 Citations
3,131 Views
14 Pages

A Comparative Study and Prediction of the Ex Vivo Permeation of Six Vaginally Administered Drugs across Five Artificial Membranes and Vaginal Tissue

  • Eleni Tsanaktsidou,
  • Aikaterini-Theodora Chatzitaki,
  • Anatoli Chatzichristou,
  • Dimitrios G. Fatouros and
  • Catherine K. Markopoulou

The theoretical interpretation of the vaginal permeability phenomenon, the evaluation of the suitability of five artificial membranes, and the prediction of the behaviors of vaginal drugs were the main objectives of this study. Franz vertical diffusi...

  • Article
  • Open Access
45 Citations
7,253 Views
26 Pages

Metronidazole Topically Immobilized Electrospun Nanofibrous Scaffold: Novel Secondary Intention Wound Healing Accelerator

  • Ahmed A. El-Shanshory,
  • Mona M. Agwa,
  • Ahmed I. Abd-Elhamid,
  • Hesham M. A. Soliman,
  • Xiumei Mo and
  • El-Refaie Kenawy

23 January 2022

The process of secondary intention wound healing includes long repair and healing time. Electrospun nanofibrous scaffolds have shown potential for wound dressing. Biopolymers have gained much attention due to their remarkable characteristics such as...