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  • Article
  • Open Access
7 Citations
2,593 Views
14 Pages

Macrocyclic Diterpenoids from Euphorbia peplus Possessing Activity Towards Autophagic Flux

  • Lu Chen,
  • Lulan Liu,
  • Yingyao Li,
  • Shipeng Guan and ,
  • Lingling Fan,
  • Xujie Qin,
  • Yingtong Di,
  • Lei Tang,
  • Rongcan Luo and
  • Ying Yan
  • + 5 authors+ 0 author

31 December 2024

Euphjatrophanes H–L (1–5), four new jatrophane-type and one new lathyrane-type diterpenoid, were isolated from Euphorbia peplus, along with eight known diterpenoids (6–13). Their structures were established on the basis of extensive...

(This article belongs to the Special Issue The Role of Bioactive Compounds in Human Health and Disease: 2nd Edition)
  • Article
  • Open Access
9 Citations
3,725 Views
21 Pages

Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology

  • Ying Yan,
  • Qi Zhou,
  • Xiaoqian Ran,
  • Qingyun Lu and ,
  • Cuishan Zhang,
  • Mingyou Peng,
  • Lei Tang,
  • Rongcan Luo,
  • Yingtong Di and
  • Xiaojiang Hao
  • + 5 authors+ 0 author

Ten jatrophane diterpenoids were isolated from the whole plant Euphorbia peplus Linn. including seven new ones, named euphjatrophanes A-G (labeled compounds 1, 2, 4–8). Their structures were elucidated with a combination of spectroscopic and si...

(This article belongs to the Special Issue Natural Bioactive Compounds for Human Health)
  • Article
  • Open Access
360 Views
16 Pages

Jatrophane Diterpenoids from Euphorbia peplus with LysoTracker-Associated Cellular Activity

  • Mingrui Yuan,
  • Shipeng Guan,
  • Bowen Ouyang,
  • Zifei Xu and ,
  • Peng Wang,
  • Qing Zhao,
  • Chonglin Yang,
  • Xiaojiang Hao,
  • Qiuyuan Yin and
  • Yingtong Di
  • + 5 authors+ 0 author

28 August 2026

Dysregulation of the autophagy–lysosome pathway is implicated in neurodegenerative disorders. To extend the chemical diversity of jatrophane diterpenoids from Euphorbia peplus and evaluate lysosome-associated phenotypes, phytochemical isolation...

(This article belongs to the Section Natural Products Chemistry)