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3 Results Found

  • Article
  • Open Access
10 Citations
6,598 Views
19 Pages

Computational Analysis Reveals Monomethylated Triazolopyrimidine as a Novel Inhibitor of SARS-CoV-2 RNA-Dependent RNA Polymerase (RdRp)

  • Anandakrishnan Karthic,
  • Veerbhan Kesarwani,
  • Rahul Kunwar Singh,
  • Pavan Kumar Yadav and ,
  • Navaneet Chaturvedi,
  • Pallavi Chauhan,
  • Brijesh Singh Yadav and
  • Sandeep Kumar Kushwaha
  • + 3 authors+ 0 author

26 January 2022

The human population is still facing appalling conditions due to several outbreaks of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus. The absence of specific drugs, appropriate vaccines for mutants, and knowledge of potential ther...

  • Article
  • Open Access
9 Citations
4,238 Views
16 Pages

Novel [1,3,4]Thiadiazole[3,2-a]pyrimidin-5-ones as Promising Biofilm Dispersal Agents against Relevant Gram-Positive and Gram-Negative Pathogens

  • Daniela Carbone,
  • Camilla Pecoraro,
  • Fabio Scianò,
  • Valentina Catania and ,
  • Domenico Schillaci,
  • Barbara Manachini,
  • Stella Cascioferro,
  • Patrizia Diana and
  • Barbara Parrino
  • + 4 authors+ 0 author

15 March 2024

Biofilm-associated infections pose significant challenges in healthcare settings due to their resistance to conventional antimicrobial therapies. In the last decade, the marine environment has been a precious source of bioactive molecules, including...

(This article belongs to the Special Issue Marine Drug Research in Italy)
  • Article
  • Open Access
19 Citations
12,161 Views
16 Pages

Characterization of Streptomyces Species and Validation of Antimicrobial Activity of Their Metabolites through Molecular Docking

  • Sobika Bhandari,
  • Bibek Raj Bhattarai,
  • Ashma Adhikari,
  • Babita Aryal and ,
  • Asmita Shrestha,
  • Niraj Aryal,
  • Uttam Lamichhane,
  • Ranjita Thapa,
  • Bijaya B. Thapa and
  • Niranjan Parajuli
  • + 9 authors+ 4 authors

21 October 2022

Finding new antibacterial agents from natural products is urgently necessary to address the growing cases of antibiotic-resistant pathogens. Actinomycetes are regarded as an excellent source of therapeutically important secondary metabolites includin...

(This article belongs to the Section Biological Processes and Systems)