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MDPIMDPI

8 Results Found

  • Review
  • Open Access
5,419 Views
14 Pages
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Hypersensitivity Reactions to Iodinated Contrast Media: A Narrative Review of Current Evidence and Clinical Challenges

  • Francesca Losa,
  • Giovanni Paoletti,
  • Linda Borgonovo,
  • Federica Buta,
  • Stefania Merli,
  • Serena Nannipieri,
  • Marta Piantanida,
  • Carlo Maria Rossi,
  • Giada Sambugaro and
  • Maria Teresa Costantino
  • + 4 authors
Healthcare2025, 13(11), 1308;https://doi.org/10.3390/healthcare13111308

30 May 2025

Background/Objectives: Hypersensitivity reactions (HSRs) to iodinated contrast media (ICM), both immediate and non-immediate, pose clinical challenges despite using low-osmolality agents. This review aims to summarize current diagnostic approaches, c...

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  • Article
  • Open Access
867 Views
12 Pages
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Evaluating the Effect of Drug Provocation Tests on Anxiety and Hopelessness Levels

  • Gürgün Tuğçe Vural Solak,
  • Kurtuluş Aksu,
  • Melis Yağdıran,
  • Fatma Dindar Çelik,
  • Özgür Akkale,
  • Onur Telli,
  • Hatice Çelik Tuğlu,
  • Nur Betül Baştuğ İnan,
  • Özge Göktürk and
  • Yavuzalp Solak
  • + 1 author
Medicina2025, 61(6), 1014;https://doi.org/10.3390/medicina61061014

29 May 2025

Background and Objectives: Drug provocation tests (DPTs) diagnose drug hypersensitivity reactions (DHRs) and identify safe alternatives. DHRs contribute to patient anxiety. The aim of this study was to evaluate anxiety and hopelessness levels before...

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  • Article
  • Open Access
6 Citations
5,060 Views
15 Pages
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Diagnostic Value of Oral Provocation Tests in Drug Hypersensitivity Reactions Induced by Nonsteroidal Anti-Inflammatory Drugs and Paracetamol

  • Iwona Popiolek,
  • Magdalena Blasiak,
  • Aleksandra Kozak,
  • Ewelina Pietak,
  • Malgorzata Bulanda and
  • Grzegorz Porebski
Diagnostics2022, 12(12), 3074;https://doi.org/10.3390/diagnostics12123074

7 December 2022

Oral drug provocation tests (DPT) are the basic diagnostic tool for the detection of hypersensitivity to non-opioid analgesics and for selecting a safe alternative for a patient. They are of great practical importance due to their common use, but the...

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  • Review
  • Open Access
29 Citations
10,124 Views
20 Pages
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Pro and Contra: Provocation Tests in Drug Hypersensitivity

  • Ozge Soyer,
  • Umit Murat Sahiner and
  • Bulent Enis Sekerel
Int. J. Mol. Sci.2017, 18(7), 1437;https://doi.org/10.3390/ijms18071437

4 July 2017

Drug provocation test (DPT) is the controlled administration of a drug to diagnose immune- or non-immune-mediated drug hypersensitivity and the last step for accurate recognition of drug hypersensitivity reactions when the previous diagnostic evaluat...

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  • Article
  • Open Access
2 Citations
2,223 Views
14 Pages
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Specific IgE and Basophil Activation Test by Microarray: A Promising Tool for Diagnosis of Platinum Compound Hypersensitivity Reactions

  • Carlos Fernández-Lozano,
  • Claudia Geraldine Rita,
  • Alicia Barra-Castro,
  • Belén de la Hoz Caballer,
  • Ernesto Roldán,
  • Cristina Pueyo López,
  • Javier Martinez-Botas and
  • María Pilar Berges-Gimeno
Int. J. Mol. Sci.2024, 25(7), 3890;https://doi.org/10.3390/ijms25073890

31 March 2024

Drug hypersensitivity reactions (DHRs) to platinum-based compounds (PCs) are on the rise, and their personalized and safe management is essential to enable first-line treatment for these cancer patients. This study aimed to evaluate the usefulness of...

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  • Article
  • Open Access
2 Citations
2,508 Views
15 Pages
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Is a Drug Allergy in a Patient’s History Real? Our Experience with Diagnostic Drug Provocation Tests

  • Begum Gorgulu Akin,
  • Betul Ozdel Ozturk,
  • Makbule Seda Bayrak Durmaz,
  • Ozge Ozturk Aktas and
  • Sadan Soyyigit
Medicina2025, 61(3), 386;https://doi.org/10.3390/medicina61030386

23 February 2025

Background and Objectives: Early-type drug hypersensitivity reactions (DHRs) are observed within the first 1–6 h and most commonly manifest as urticaria and/or angioedema. Detailed anamnesis, skin prick tests (SPTs), intradermal tests (IDTs), a...

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  • Article
  • Open Access
2 Citations
2,105 Views
12 Pages
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Patient Adherence to Written Instructions following Complete Allergological Evaluation for Suspected Beta-Lactam Allergy: A Tertiary Hospital Study in Greece

  • Michael Makris,
  • Niki Papapostolou,
  • Maria Pasali,
  • Xenofon Aggelidis,
  • Caterina Chliva and
  • Alexander C. Katoulis
J. Pers. Med.2023, 13(12), 1719;https://doi.org/10.3390/jpm13121719

17 December 2023

Background: Beta-lactam (BL) antibiotics are among the most prescribed groups of drugs worldwide and have been implicated in a variety of allergic reactions. There is a paucity of literature regarding patient adherence to prescribed instructions foll...

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  • Article
  • Open Access
18 Citations
3,304 Views
10 Pages
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Detection of Serum-Specific IgE by Fluoro-Enzyme Immunoassay for Diagnosing Type I Hypersensitivity Reactions to Penicillins

  • Adriana Ariza,
  • Cristobalina Mayorga,
  • Gádor Bogas,
  • Francesco Gaeta,
  • María Salas,
  • Rocco L. Valluzzi,
  • Marina Labella,
  • Natalia Pérez-Sánchez,
  • Cristiano Caruso and
  • Antonino Romano
  • + 3 authors
Int. J. Mol. Sci.2022, 23(13), 6992;https://doi.org/10.3390/ijms23136992

23 June 2022

Diagnosis of type I hypersensitivity reactions (IgE-mediated reactions) to penicillins is based on clinical history, skin tests (STs), and drug provocation tests (DPTs). Among in vitro complementary tests, the fluoro-enzyme immunoassay (FEIA) ImmunoC...

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