Next Article in Journal
Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation
Next Article in Special Issue
Structural Elements Recognized by Abacavir-Induced T Cells
Previous Article in Journal
A Novel Therapeutic Approach in the Treatment of Pulmonary Arterial Hypertension: Allium ursinum Liophylisate Alleviates Symptoms Comparably to Sildenafil
Previous Article in Special Issue
Drug Hypersensitivity and Desensitizations: Mechanisms and New Approaches
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(7), 1437;

Pro and Contra: Provocation Tests in Drug Hypersensitivity

Department of Pediatric Allergy Ankara, School of Medicine, Hacettepe University, Ankara 06100, Turkey
Author to whom correspondence should be addressed.
Received: 21 May 2017 / Revised: 24 June 2017 / Accepted: 27 June 2017 / Published: 4 July 2017
(This article belongs to the Special Issue Drug Hypersensitivity)
Full-Text   |   PDF [1260 KB, uploaded 5 July 2017]   |  


Drug provocation test (DPT) is the controlled administration of a drug to diagnose immune- or non-immune-mediated drug hypersensitivity and the last step for accurate recognition of drug hypersensitivity reactions when the previous diagnostic evaluations are negative or unavailable. A DPT is performed only if other conventional tests fail to yield conclusive results. In each clinical presentation, “to provoke or not to provoke” a patient should be decided after careful assessment of the risk–benefit ratio. Well-defined benefits of DPT include confirmative exclusion of diagnoses of drug hypersensitivity and provision of safe alternatives. However, disadvantages such as safety, difficulty in interpretations of results, lack of objective biomarkers, risks of resensitization, efficiency in daily practice, and lack of standardized protocols, are poorly debated. This review summarizes the current published research concerning DPT, with particular emphasis on the advantages and disadvantages of DPT in an evidence-based manner. View Full-Text
Keywords: drug hypersensitivity reaction; provocation test; anaphylaxis drug hypersensitivity reaction; provocation test; anaphylaxis

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Soyer, O.; Sahiner, U.M.; Sekerel, B.E. Pro and Contra: Provocation Tests in Drug Hypersensitivity. Int. J. Mol. Sci. 2017, 18, 1437.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top