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  • Open Access
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A Novel Two-Step Liquid-Liquid Extraction Procedure Combined with Stationary Phase Immobilized Human Serum Albumin for the Chiral Separation of Cetirizine Enantiomers along with M and P Parabens

  • Aleksandra Chmielewska,
  • Lucyna Konieczna and
  • Tomasz Bączek
Molecules2016, 21(12), 1654;https://doi.org/10.3390/molecules21121654

7 December 2016

The research into the separation of drug enantiomers is closely related to the safety and efficiency of the drugs. The aim of this study was to develop a simple and validated HPLC method to analyze cetirizine enantiomers. In the case of liquid dosage...

(This article belongs to the Special Issue Chromatographic Separation of Enantiomers: Commemorative Issue in Honor of Professor Stig Allenmark on the Occasion of His 80th Birthday)
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  • Communication
  • Open Access
5 Citations
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9 Pages
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Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (S)-Cetirizine by Lys191 in Human Histamine H1 Receptors

  • Shigeru Hishinuma,
  • Yuri Tamura,
  • Chihiro Kobayashi,
  • Chizuru Akatsu and
  • Masaru Shoji
Int. J. Mol. Sci.2018, 19(12), 4067;https://doi.org/10.3390/ijms19124067

15 December 2018

Cetirizine is a zwitterionic second-generation antihistamine containing R- and S-enantiomers, levocetirizine, and (S)-cetirizine. Levocetirizine is known to have a higher affinity for the histamine H1 receptors than (S)-cetirizine; ligand-receptor do...

(This article belongs to the Special Issue Histamine-Related Molecules as Therapeutic Targets)
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