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10 Citations

4,508 Views

13 Pages

Substrate Selectivity of a Novel Amylo-α-1,6-glucosidase from Thermococcus gammatolerans STB12

Yamei Wang,
Yixiong Tian,
Xiaofeng Ban,
Caiming Li,
Yan Hong,
Li Cheng,
Zhengbiao Gu and
Zhaofeng Li

Foods2022, 11(10), 1442;https://doi.org/10.3390/foods11101442

16 May 2022

Amylo-α-1,6-glucosidase (EC 3.2.1.33, AMY) exhibits hydrolytic activity towards α-1,6-glycosidic bonds of branched substrates. The debranching products of maltodextrin, waxy corn starch and cassava starch treated with AMY, pullulanase (EC...

(This article belongs to the Special Issue Application of Enzyme Engineering in Food)

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525 Views

13 Pages

Off-Target Binding of Miglustat to Glycogen Debranching Enzyme

Drew Barber,
Neha Mishra,
Fiona Hegarty and
Aviv Paz

Int. J. Mol. Sci.2026, 27(12), 5490;https://doi.org/10.3390/ijms27125490

17 June 2026

The iminosugar N-butyldeoxynojirimycin (Miglustat) is clinically used for the inhibition of ceramide glucosyltransferase for treating Type 1 Gaucher and Niemann–Pick type C diseases. This drug also inhibits glycogen debranching enzyme (GDE), th...

(This article belongs to the Special Issue Structural and Functional Insights into Membrane Transporters: A Tribute to Dr. Ernest Wright)

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