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Review

69 Citations

11,988 Views

25 Pages

Role of the Mre11 Complex in Preserving Genome Integrity

Julyun Oh and
Lorraine S. Symington

Genes2018, 9(12), 589;https://doi.org/10.3390/genes9120589

29 November 2018

DNA double-strand breaks (DSBs) are hazardous lesions that threaten genome integrity and cell survival. The DNA damage response (DDR) safeguards the genome by sensing DSBs, halting cell cycle progression and promoting repair through either non-homolo...

(This article belongs to the Special Issue Chromosome Replication and Genome Integrity)

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Review

11 Citations

4,319 Views

16 Pages

Dynamic Properties of the DNA Damage Response Mre11/Rad50 Complex

Jacopo Vertemara and
Renata Tisi

Int. J. Mol. Sci.2023, 24(15), 12377;https://doi.org/10.3390/ijms241512377

3 August 2023

DNA double-strand breaks (DSBs) are a significant threat to cell viability due to the induction of genome instability and the potential loss of genetic information. One of the key players for early DNA damage response is the conserved Mre11/Rad50 Nbs...

(This article belongs to the Special Issue Computational Approaches for the Investigation of Complex Molecular Mechanisms 2.0)

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