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Article

35 Citations

9,702 Views

20 Pages

Human Endogenous Retrovirus Group E and Its Involvement in Diseases

Christelle Le Dantec,
Sophie Vallet,
Wesley H. Brooks and
Yves Renaudineau

Viruses2015, 7(3), 1238-1257;https://doi.org/10.3390/v7031238

16 March 2015

Human endogenous retrovirus group E (HERV-E) elements are stably integrated into the human genome, transmitted vertically in a Mendelian manner, and are endowed with transcriptional activity as alternative promoters or enhancers. Such effects are und...

(This article belongs to the Special Issue Endogenous Viruses)

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Review

61 Citations

8,987 Views

12 Pages

Human Endogenous Retroviruses (HERVs): Shaping the Innate Immune Response in Cancers

Vincent Alcazer,
Paola Bonaventura and
Stephane Depil

Cancers2020, 12(3), 610;https://doi.org/10.3390/cancers12030610

6 March 2020

Human Endogenous Retroviruses (HERVs) are accounting for 8% of the human genome. These sequences are remnants from ancient germline infections by exogenous retroviruses. After million years of evolution and multiple integrations, HERVs have acquired...

(This article belongs to the Special Issue Targeting Innate Immunity Cells in Cancer)

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