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8 Results Found

  • Article
  • Open Access
6 Citations
3,263 Views
20 Pages
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Differentially Expressed Genes in Response to a Squalene-Supplemented Diet Are Accurate Discriminants of Porcine Non-Alcoholic Steatohepatitis

  • Roubi Abuobeid,
  • Luis V. Herrera-Marcos,
  • Carmen Arnal,
  • Seyed Hesamoddin Bidooki,
  • Javier Sánchez-Marco,
  • Roberto Lasheras,
  • Joaquín C. Surra,
  • María Jesús Rodríguez-Yoldi,
  • Roberto Martínez-Beamonte and
  • Jesús Osada
Int. J. Mol. Sci.2023, 24(16), 12552;https://doi.org/10.3390/ijms241612552

8 August 2023

Squalene is the major unsaponifiable component of virgin olive oil, the fat source of the Mediterranean diet. To evaluate its effect on the hepatic transcriptome, RNA sequencing was carried out in two groups of male Large White x Landrace pigs develo...

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  • Open Access
9 Citations
3,847 Views
24 Pages
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RNA-Seq Analysis of UPM-Exposed Epithelium Co-Cultivated with Macrophages and Dendritic Cells in Obstructive Lung Diseases

  • Paulina Misiukiewicz-Stępien,
  • Michał Mierzejewski,
  • Elwira Zajusz-Zubek,
  • Krzysztof Goryca,
  • Dorota Adamska,
  • Michał Szeląg,
  • Rafał Krenke and
  • Magdalena Paplińska-Goryca
Int. J. Mol. Sci.2022, 23(16), 9125;https://doi.org/10.3390/ijms23169125

15 August 2022

Background. Elevated concentrations of airborne pollutants are correlated with an enlarged rate of obstructive lung disease morbidity as well as acute disease exacerbations. This study aimed to analyze the epithelium mRNA profile in response to airbo...

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  • Article
  • Open Access
1 Citations
2,412 Views
15 Pages
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Transcriptome Analysis Revealed Genes Related to γ-Irradiation Induced Emergence Failure in Third-Instar Larvae of Bactrocera dorsalis

  • Chao Sun,
  • Samina Shabbir,
  • Wenxiang Wang,
  • Yan Gao,
  • Cuicui Ge and
  • Qingsheng Lin
Insects2022, 13(11), 1017;https://doi.org/10.3390/insects13111017

3 November 2022

The oriental fruit fly is a polyphagous and highly invasive economically important pest in the world. We proposed the hypothesis that radiation treatment influence RNA expression in the larvae and leads to emergence failure. Therefore, transcriptome...

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  • Article
  • Open Access
3 Citations
2,581 Views
17 Pages
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Identification of Schizophrenia Susceptibility Loci in the Urban Taiwanese Population

  • Chih-Chung Huang,
  • Yi-Guang Wang,
  • Chun-Lun Hsu,
  • Ta-Chuan Yeh,
  • Wei-Chou Chang,
  • Ajeet B. Singh,
  • Chin-Bin Yeh,
  • Yi-Jen Hung,
  • Kuo-Sheng Hung and
  • Hsin-An Chang
Medicina2024, 60(8), 1271;https://doi.org/10.3390/medicina60081271

6 August 2024

Background and Objectives: Genomic studies have identified several SNP loci associated with schizophrenia in East Asian populations. Environmental factors, particularly urbanization, play a significant role in schizophrenia development. This study ai...

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  • Open Access
49 Citations
4,956 Views
11 Pages
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Selection Signatures Analysis Reveals Genes Associated with High-Altitude Adaptation in Tibetan Goats from Nagqu, Tibet

  • Meilin Jin,
  • Jian Lu,
  • Xiaojuan Fei,
  • Zengkui Lu,
  • Kai Quan,
  • Yongbin Liu,
  • Mingxing Chu,
  • Ran Di,
  • Caihong Wei and
  • Huihua Wang
Animals2020, 10(9), 1599;https://doi.org/10.3390/ani10091599

8 September 2020

Tibetan goat is an ancient breed, which inhabits the adverse conditions of the plateaus in China. To investigate the role of selection in shaping its genomes, we genotyped Tibetan goats (Nagqu Prefecture, above 4500 m) and three lowland populations (...

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  • Open Access
1,853 Views
24 Pages
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Comparison Bioinformatic Analysis of Extracellular Vesicles-Related Genes and MicroRNAs in Breast Cancer

  • Durmus Ayan,
  • Serife Buket Bozkurt Polat,
  • Esma Ozmen and
  • Mehmet Ali Gul
Int. J. Mol. Sci.2025, 26(12), 5906;https://doi.org/10.3390/ijms26125906

19 June 2025

Breast cancer (BC) remains a leading cause of cancer-related mortality in women, with treatment challenges due to the lack of targeted therapies. Extracellular vesicles (EVs) play a crucial role in BC progression by carrying bioactive molecules. This...

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  • Open Access
1 Citations
1,070 Views
23 Pages
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Host–Microbiota Interactions in the Pathogenesis of Porcine Fetal Mummification

  • Mingyu Wang,
  • Lin Zhang,
  • Zhe Liu,
  • Ao Guo,
  • Gongshe Yang and
  • Taiyong Yu
Microorganisms2025, 13(5), 1052;https://doi.org/10.3390/microorganisms13051052

30 April 2025

The number of mummies (MUM) in pigs is a major factor affecting sow reproductive performance. Reducing the incidence of MUM can effectively improve sow utilization efficiency. However, the complex mechanisms by which the host genome, gut microbiome,...

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  • Open Access
335 Views
17 Pages
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Transcriptomic Analysis of Gene Expression Patterns in the Cecal Tissue of Liangshan Yanying Chickens and Arbor Acres (AA) Chickens Before 28 Days of Age

  • Zengwen Huang,
  • Jing Wang,
  • Chaoyun Yang and
  • Runjin Wang
Animals2026, 16(3), 474;https://doi.org/10.3390/ani16030474

3 February 2026

To dissect the molecular mechanisms underlying chicken cecal development, this study used Liangshan Yanying chickens (a local slow-growing breed) and Arbor Acres (AA) chickens (a fast-growing breed) as experimental models. Cecal tissues were collecte...

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