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Article

9 Citations

3,777 Views

25 Pages

TGFβ Inhibitor A83-01 Enhances Murine HSPC Expansion for Gene Therapy

Jenni Fleischauer,
Antonella Lucia Bastone,
Anton Selich,
Philipp John-Neek,
Luisa Weisskoeppel,
Dirk Schaudien,
Axel Schambach and
Michael Rothe

Cells2023, 12(15), 1978;https://doi.org/10.3390/cells12151978

31 July 2023

Murine hematopoietic stem and progenitor cells (HSPCs) are commonly used as model systems during gene therapeutic retroviral vector development and preclinical biosafety assessment. Here, we developed cell culture conditions to maintain stemness and...

(This article belongs to the Special Issue Gene and Cell Therapy in Regenerative Medicine)

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Article

8 Citations

4,940 Views

12 Pages

5-Aza-2′-Deoxycytidine and Valproic Acid in Combination with CHIR99021 and A83-01 Induce Pluripotency Genes Expression in Human Adult Somatic Cells

Alain Aguirre-Vázquez,
Luis A. Salazar-Olivo,
Xóchitl Flores-Ponce,
Ana L. Arriaga-Guerrero,
Dariela Garza-Rodríguez,
María E. Camacho-Moll,
Iván Velasco,
Fabiola Castorena-Torres,
Nidheesh Dadheech and
Mario Bermúdez de León

Molecules2021, 26(7), 1909;https://doi.org/10.3390/molecules26071909

29 March 2021

A generation of induced pluripotent stem cells (iPSC) by ectopic expression of OCT4, SOX2, KLF4, and c-MYC has established promising opportunities for stem cell research, drug discovery, and disease modeling. While this forced genetic expression repr...

(This article belongs to the Special Issue Small Molecules in Drug Discovery and Pharmacology)

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