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  • Open Access
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Stereoselective Synthesis and Structural Confirmation of All Four 8-Hydroxyhexahydrocannabinol Stereoisomers

  • Kei Ieuji,
  • Kayo Nakamura and
  • Hideyo Takahashi
Molecules2026, 31(2), 289;https://doi.org/10.3390/molecules31020289

13 January 2026

Hexahydrocannabinol (HHC), a hydrogenated derivative of Δ9-tetrahydrocannabinol (Δ9-THC), is a semi-synthetic cannabinoid marketed as an alternative to Δ9-THC. Its hydroxylated metabolite, 8-hydroxyhexahydrocannabinol (8-OH-HHC), ex...

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  • Article
  • Open Access
13 Citations
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Evidence of 11-Hydroxy-hexahydrocannabinol and 11-Nor-9-carboxy-hexahydrocannabinol as Novel Human Metabolites of Δ9-Tetrahydrocannabinol

  • Christian Falck Jørgensen,
  • Brian Schou Rasmussen,
  • Kristian Linnet and
  • Ragnar Thomsen
Metabolites2023, 13(12), 1169;https://doi.org/10.3390/metabo13121169

23 November 2023

(−)-trans-Δ9-tetrahydrocannabinol (Δ9-THC) is the primary psychoactive compound in the Cannabis sativa plant. Δ9-THC undergoes extensive metabolism, with the main human phase I metabolites being 11-hydroxy-tetrahydrocannabinol...

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