Biomedicines | Hot Papers in the “Gene and Cell Therapy” Section

The “Gene and Cell Therapy” Section publishes reviews and original peer-reviewed papers. This section of Biomedicines aims to rapidly publish contributions on all aspects of the latest research results concerning gene and cell therapy. We encourage submissions of manuscripts that provide novel and mechanistic insights, including but not limited to gene transfer; vector development and design; autologous and allogeneic cell therapies (hematopoietic and mesenchymal stem cell therapies); the development of genes, peptides, proteins, oligonucleotides, and cell therapies to correct genetic and acquired diseases; vaccine development; preclinical target validation; and other research aspects. In this context, we are pleased to feature some recently published papers from the “Gene and Cell Therapy” Section in Biomedicines (ISSN 2227-9059), which will provide valuable insights into this exciting field.

1. “Advances and Challenges in the Pursuit of Disease-Modifying Osteoarthritis Drugs: A Review of 2010–2024 Clinical Trials”
by Mckenzie D. Brandt, Jason B. Malone and Thomas J. Kean
Biomedicines 2025, 13(2), 355; https://doi.org/10.3390/biomedicines13020355
Available online: https://www.mdpi.com/2227-9059/13/2/355

2. “Scientific Advancements in Gene Therapies: Opportunities for Global Regulatory Convergence”
by Jimi Olaghere, David A. Williams, Jeremy Farrar, Hildegard Büning, Cecelia Calhoun, Tony Ho, Maneesha S. Inamdar, David Liu, Julie Makani, Anouck Coulange Zavarro et al.
Biomedicines 2025, 13(3), 758; https://doi.org/10.3390/biomedicines13030758
Available online: https://www.mdpi.com/2227-9059/13/3/758

3. “Novel Interventions on Comorbidities in Patients with Fetal Alcohol Spectrum Disorder (FASD): An Integrative Review”
by Vicente Andreu-Fernández, Nunzia La Maida, Maribel Marquina, Afrouz Mirahi, Oscar García-Algar, Simona Pichini and Adele Minutillo
Biomedicines 2024, 12(3), 496; https://doi.org/10.3390/biomedicines12030496
Available online: https://www.mdpi.com/2227-9059/12/3/496

4. “Pathophysiology in Brain Arteriovenous Malformations: Focus on Endothelial Dysfunctions and Endothelial-to-Mesenchymal Transition”
by Jae Yeong Jeong, Adrian E. Bafor, Bridger H. Freeman, Peng R. Chen, Eun S. Park and Eunhee Kim
Biomedicines 2024, 12(8), 1795; https://doi.org/10.3390/biomedicines12081795
Available online: https://www.mdpi.com/2227-9059/12/8/1795

5. “Stem Cell Therapy for Myocardial Infarction Recovery: Advances, Challenges, and Future Directions”
by Nicholas T. Le, Matthew W. Dunleavy, William Zhou, Sumrithbir S. Bhatia, Rebecca D. Kumar, Suyin T. Woo, Gonzalo Ramirez-Pulido, Kaushik S. Ramakrishnan and Ahmed H. El-Hashash
Biomedicines 2025, 13(5), 1209; https://doi.org/10.3390/biomedicines13051209
Available online: https://www.mdpi.com/2227-9059/13/5/1209

6. “The Impacts of Intervertebral Disc Degeneration of the Spine, Alcohol Consumption, Smoking Tobacco Products, and Glycemic Disorders on the Expression Profiles of Neurotrophins-3 and -4”
by Rafał Staszkiewicz, Dorian Gładysz, Dawid Sobański, Filip Bolechała, Edward Golec, Werner Dammermann and Beniamin Oskar Grabarek
Biomedicines 2024, 12(2), 427; https://doi.org/10.3390/biomedicines12020427
Available online: https://www.mdpi.com/2227-9059/12/2/427

7. “Ten-Year Persistence of Biologic Drugs in Psoriasis and Its Relationship with Pharmacogenetic Biomarkers”
by Andrea Rodríguez-Lopez, María Martínez-Sendino, Rocío Prieto-Pérez, Paula Soria-Chacartegui, Eva González-Iglesias, Mario Aparicio-Domínguez, Sonsoles Berenguer-Ruiz, Esteban Daudén and Francisco Abad-Santos
Biomedicines 2025, 13(1), 5; https://doi.org/10.3390/biomedicines13010005
Available online: https://www.mdpi.com/2227-9059/13/1/5

8. “Therapeutic Opportunities in Melanoma Through PRAME Expression”
by Mislav Mokos, Ivana Prkačin, Klara Gaćina, Ana Brkić, Nives Pondeljak and Mirna Šitum
Biomedicines 2025, 13(8), 1988; https://doi.org/10.3390/biomedicines13081988
Available online: https://www.mdpi.com/2227-9059/13/8/1988

9. “Considerations for the Use of Stereotactic Radiosurgery to Treat Large Arteriovenous Malformations”
by Jong Hyun Lim and Myung Ji Kim
Biomedicines 2024, 12(9), 2003; https://doi.org/10.3390/biomedicines12092003
Available online: https://www.mdpi.com/2227-9059/12/9/2003

10. “Adjuvant Immunotherapy in Stage IIB/IIC Melanoma: Current Evidence and Future Directions”
by Ivana Prkačin, Ana Brkić, Nives Pondeljak, Mislav Mokos, Klara Gaćina and Mirna Šitum
Biomedicines 2025, 13(8), 1894; https://doi.org/10.3390/biomedicines13081894
Available online: https://www.mdpi.com/2227-9059/13/8/1894

To acknowledge the above authors' excellent contributions, we are happy to provide a full waiver to each team of the above publications. We also would like to take this opportunity to thank all the research groups that have submitted to Biomedicines (ISSN 2227-9059). We would appreciate it if you would circulate this document among your colleagues and networks. Furthermore, the following opportunities for collaboration may be of interest to you:

Submitting a manuscript:
This “Gene and Cell Therapy” Section is currently open for submissions. Papers may be submitted via the following link: https://www.mdpi.com/user/manuscripts/upload/?journal=biomedicines.

Joining the Volunteer Reviewer Board:
If you are an active researcher in the fields of biomedical research and are interested in joining the Volunteer Reviewer Board of Biomedicines, please do not hesitate to submit your application via the following link: https://susy.mdpi.com/volunteer/profile/edit.

Biomedicines Editorial Office